About the Authors

Verónica Martín

Current address: Centro de Investigación en Sanidad Animal (CISA-INIA), Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria. Valdeolmos, Madrid, Spain.

Affiliation Centro de Biología Molecular ‘Severo Ochoa’ (CBMSO, CSIC-UAM). Campus de Cantoblanco, Madrid, Spain

Celia Perales

Affiliations Centro de Biología Molecular ‘Severo Ochoa’ (CBMSO, CSIC-UAM). Campus de Cantoblanco, Madrid, Spain, Centro de Investigación Biomédica en Red de enfermedades hepáticas y digestivas (CIBERehd), Spain, Liver Unit, Internal Medicine, Laboratory of Malalties Hepàtiques, Vall d’Hebron Institut de Recerca-Hospital Universitari Vall d´Hebron (VHIR-HUVH), Universitat Autònoma de Barcelona. Barcelona, Spain

María Fernández-Algar

Affiliation Department of Molecular Evolution, Centro de Astrobiología (CAB, CSIC-INTA). Torrejón de Ardoz, Madrid, Spain

Helena G. Dos Santos

Current address: Department of Biological Sciences, Florida International University. Miami, FL, United States of America.

Affiliation Centro de Biología Molecular ‘Severo Ochoa’ (CBMSO, CSIC-UAM). Campus de Cantoblanco, Madrid, Spain

Patricia Garrido

Current address: Sygnis Biotech. Parque Científico de Madrid. Campus de Cantoblanco, Madrid, Spain.

Affiliation Biotherapix, SLU. Parque Tecnológico de Madrid, Tres Cantos, Madrid. Spain

María Pernas

Current address: Instituto de Salud Carlos III. Majadahonda, Madrid, Spain.

Affiliation Biotherapix, SLU. Parque Tecnológico de Madrid, Tres Cantos, Madrid. Spain

Víctor Parro

Affiliation Department of Molecular Evolution, Centro de Astrobiología (CAB, CSIC-INTA). Torrejón de Ardoz, Madrid, Spain

Miguel Moreno

Affiliation Department of Molecular Evolution, Centro de Astrobiología (CAB, CSIC-INTA). Torrejón de Ardoz, Madrid, Spain

Javier García-Pérez

Affiliation AIDS Immunopathogenesis Unit, Instituto de Salud Carlos III. Majadahonda, Madrid, Spain

José Alcamí

Affiliation AIDS Immunopathogenesis Unit, Instituto de Salud Carlos III. Majadahonda, Madrid, Spain

José Luis Torán

Current address: Spanish National Center for Biotechnology (CNB, CSIC). Campus de Cantoblanco, Madrid, Spain.

Affiliation Biotherapix, SLU. Parque Tecnológico de Madrid, Tres Cantos, Madrid. Spain

David Abia

Affiliation Centro de Biología Molecular ‘Severo Ochoa’ (CBMSO, CSIC-UAM). Campus de Cantoblanco, Madrid, Spain

Esteban Domingo

Affiliations Centro de Biología Molecular ‘Severo Ochoa’ (CBMSO, CSIC-UAM). Campus de Cantoblanco, Madrid, Spain, Centro de Investigación Biomédica en Red de enfermedades hepáticas y digestivas (CIBERehd), Spain

Carlos Briones

cbriones@cab.inta-csic.es

Affiliations Centro de Investigación Biomédica en Red de enfermedades hepáticas y digestivas (CIBERehd), Spain, Department of Molecular Evolution, Centro de Astrobiología (CAB, CSIC-INTA). Torrejón de Ardoz, Madrid, Spain

Competing Interests

We have the following interests: This study was supported by Biotherapix, S.L.U. Patricia Garrido, María Pernas and José Luis Torán were employed by Biotherapix, S.L.U. There are no patents, products in development or marketed products to declare. This does not alter our adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors.

Author Contributions

Conceptualization: ED CB. Data curation: VM CP HGDS JLT DA CB. Formal analysis: VM CP HGDS JA JLT DA ED CB. Funding acquisition: JLT ED CB. Investigation: VM CP HGDS VP MM JA JLT DA ED CB. Methodology: VM CP MF-A PG MP VP MM JG-P JLT CB. Project administration: JLT ED CB. Resources: JA JLT DA ED CB. Software: HGDS DA. Supervision: JLT DA ED CB. Validation: VM CP MF-A HGDS JG-P JA JLT DA ED CB. Visualization: VM CP HGDS MM DA CB. Writing – original draft: CB. Writing – review & editing: VM CP HGDS JA ED CB.