About the Authors

Brian Egan

egan@activemotif.com (BE); patrick.trojer@constellationpharma.com (PT)

Affiliation Active Motif Inc., Carlsbad, California, United States of America

Chih-Chi Yuan

Affiliation Constellation Pharmaceuticals Inc., Cambridge, Massachusetts, United States of America

Madeleine Lisa Craske

Affiliation Active Motif Inc., Carlsbad, California, United States of America

Paul Labhart

Affiliation Active Motif Inc., Carlsbad, California, United States of America

Gulfem D. Guler

Affiliation Department of Molecular Oncology, Genentech Inc., South San Francisco, California, United States of America

David Arnott

Affiliation Department of Protein Chemistry, Genentech Inc., South San Francisco, California, United States of America

Tobias M. Maile

Affiliation Department of Protein Chemistry, Genentech Inc., South San Francisco, California, United States of America

Jennifer Busby

Affiliation Constellation Pharmaceuticals Inc., Cambridge, Massachusetts, United States of America

Chisato Henry

Affiliation Active Motif Inc., Carlsbad, California, United States of America

Theresa K. Kelly

Affiliation Active Motif Inc., Carlsbad, California, United States of America

Charles A. Tindell

Affiliation Department of Molecular Oncology, Genentech Inc., South San Francisco, California, United States of America

Suchit Jhunjhunwala

Affiliation Department of Bioinformatics, Genentech Inc., South San Francisco, California, United States of America

Feng Zhao

Affiliation Constellation Pharmaceuticals Inc., Cambridge, Massachusetts, United States of America

Charlie Hatton

Affiliation Constellation Pharmaceuticals Inc., Cambridge, Massachusetts, United States of America

Barbara M. Bryant

Affiliation Constellation Pharmaceuticals Inc., Cambridge, Massachusetts, United States of America

Marie Classon

Contributed equally to this work with: Marie Classon, Patrick Trojer

Affiliation Department of Molecular Oncology, Genentech Inc., South San Francisco, California, United States of America

Patrick Trojer

Contributed equally to this work with: Marie Classon, Patrick Trojer

egan@activemotif.com (BE); patrick.trojer@constellationpharma.com (PT)

Affiliation Constellation Pharmaceuticals Inc., Cambridge, Massachusetts, United States of America

Competing Interests

CCY, JB, FZ, CH, BMB and PT are employees of Constellation Pharmaceuticals. GDG, DA, TM, CT, SJ, and MC are employees of Genentech Inc. BE, MLC, PL, CH and TKK are employees of Active Motif Inc. Active Motif sells the H2Av antibody and D. melanogaster chromatin to support ChIP-Seq spike-in experiments. This does not alter our adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceptualization: BE MC PT. Data curation: BE PL MC BMB PT. Formal analysis: PL SJ CH BMB. Investigation: CCY MLC GDG DA TMM JB CH CAT FZ. Methodology: BE MLC DA TKK MC PT. Project administration: BE MC PT. Resources: CCY GDG TMM JB TKK CAT FZ MC PT. Supervision: BE MLC MC PT. Validation: BE MC PT. Visualization: PL CH BMB BE MC PT. Writing – original draft: BE MC PT. Writing – review & editing: BE PT.