About the Authors

Peter C. Elwood

Contributed equally to this work with: Peter C. Elwood, Gareth Morgan, Julieta Galante, John W. K. Chia, Mark Kelson, Janet Pickering, Delyth Morris, Alison L. Weightman

Affiliation Cochrane Institute of Primary Care and Public Health, Cardiff University, Cardiff, United Kingdom

Gareth Morgan

Contributed equally to this work with: Peter C. Elwood, Gareth Morgan, Julieta Galante, John W. K. Chia, Mark Kelson, Janet Pickering, Delyth Morris, Alison L. Weightman

gareth.morgan5@wales.nhs.uk

Affiliations Cochrane Institute of Primary Care and Public Health, Cardiff University, Cardiff, United Kingdom, Hywel Dda University Health Board, Llanelli, United Kingdom

Julieta Galante

Contributed equally to this work with: Peter C. Elwood, Gareth Morgan, Julieta Galante, John W. K. Chia, Mark Kelson, Janet Pickering, Delyth Morris, Alison L. Weightman

Affiliations Cochrane Institute of Primary Care and Public Health, Cardiff University, Cardiff, United Kingdom, Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom

John W. K. Chia

Contributed equally to this work with: Peter C. Elwood, Gareth Morgan, Julieta Galante, John W. K. Chia, Mark Kelson, Janet Pickering, Delyth Morris, Alison L. Weightman

Affiliation Division of Medical Oncology, National Cancer Centre, Singapore, Singapore

Sunil Dolwani

‡ These authors also contributed equally to this work.

Affiliation Institute of Cancer & Genetics Cardiff University, Cardiff, United Kingdom

J. Michael Graziano

‡ These authors also contributed equally to this work.

Affiliation Harvard Medical School, Boston, MA, United States of America

Mark Kelson

Contributed equally to this work with: Peter C. Elwood, Gareth Morgan, Julieta Galante, John W. K. Chia, Mark Kelson, Janet Pickering, Delyth Morris, Alison L. Weightman

Affiliation Cochrane Institute of Primary Care and Public Health, Cardiff University, Cardiff, United Kingdom

Angel Lanas

‡ These authors also contributed equally to this work.

Affiliation University Clinic Hospital, University of Zaragoza, IIS Aragón, CIBEReshd, Zaragoza, Spain

Marcus Longley

‡ These authors also contributed equally to this work.

Affiliation Welsh Institute for Health and Social Care, University of South Wales, Cardiff, United Kingdom

Ceri J. Phillips

‡ These authors also contributed equally to this work.

Affiliation Swansea Centre for Health Economics, Swansea University, Swansea, United Kingdom

Janet Pickering

Contributed equally to this work with: Peter C. Elwood, Gareth Morgan, Julieta Galante, John W. K. Chia, Mark Kelson, Janet Pickering, Delyth Morris, Alison L. Weightman

Affiliation Cochrane Institute of Primary Care and Public Health, Cardiff University, Cardiff, United Kingdom

Stephen E. Roberts

‡ These authors also contributed equally to this work.

Affiliation Medical School, Swansea University, Swansea, United Kingdom

Swee S. Soon

‡ These authors also contributed equally to this work.

Affiliation Department of Pharmacy, National University of Singapore, Singapore, Singapore

Will Steward

‡ These authors also contributed equally to this work.

Affiliation Department of Cancer Studies, University of Leicester, Leicester, United Kingdom

Delyth Morris

Contributed equally to this work with: Peter C. Elwood, Gareth Morgan, Julieta Galante, John W. K. Chia, Mark Kelson, Janet Pickering, Delyth Morris, Alison L. Weightman

Affiliation University Library Services, Cardiff University, Cardiff, United Kingdom

Alison L. Weightman

Contributed equally to this work with: Peter C. Elwood, Gareth Morgan, Julieta Galante, John W. K. Chia, Mark Kelson, Janet Pickering, Delyth Morris, Alison L. Weightman

Affiliations Cochrane Institute of Primary Care and Public Health, Cardiff University, Cardiff, United Kingdom, Specialist Unit for Review Evidence (SURE), Cardiff University, Cardiff, United Kingdom

Competing Interests

We have the following conflicts: PCE was an advisor to Bayer HealthCare and was until recently a member of the Board of the International Aspirin Foundation. JMG is a consultant to Bayer and the Chair of the executive committee for the ARRIVE trial which is sponsored by Bayer. AL has participated in Advisory Boards organized by Bayer Pharma AG. JWKC has previously participated in Advisory Boards by Bayer AG. This does not alter our adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceptualization: GM PCE SD JG JMG AL ML SSS WS CJP SR ALW. Data curation: PCE GM ALW DM. Formal analysis: ALW DM JP MK AL. Funding acquisition: ALW PCE. Methodology: GM ALW DM JP JG PCE. Writing – original draft: PCE GM. Writing – review & editing: PCE GM JWKC JG JP MK ALW.