About the Authors

Jin Xu

Affiliation Department of Dermatology, Stanford University School of Medicine, Redwood City, California, United States of America

Robert C. Spitale

Affiliation Department of Pharmaceutical Sciences, University of California Irvine, Irvine, California, United States of America

Linna Guan

Affiliation Department of Dermatology, Stanford University School of Medicine, Redwood City, California, United States of America

Ryan A. Flynn

Affiliation Department of Dermatology, Stanford University School of Medicine, Redwood City, California, United States of America

Eduardo A. Torre

Affiliation Department of Dermatology, Stanford University School of Medicine, Redwood City, California, United States of America

Rui Li

Affiliation Department of Dermatology, Stanford University School of Medicine, Redwood City, California, United States of America

Inbar Raber

Affiliation Department of Dermatology, Stanford University School of Medicine, Redwood City, California, United States of America

Kun Qu

Affiliation Department of Dermatology, Stanford University School of Medicine, Redwood City, California, United States of America

Dale Kern

Affiliation Nu Skin International, Provo, Utah, United States of America

Helen E. Knaggs

Affiliation Nu Skin International, Provo, Utah, United States of America

Howard Y. Chang

Affiliation Department of Dermatology, Stanford University School of Medicine, Redwood City, California, United States of America

Anne Lynn S. Chang

alschang@stanford.edu

Current address: Department of Dermatology, Stanford University School of Medicine, Redwood City, California, United States of America

Affiliation Department of Dermatology, Stanford University School of Medicine, Redwood City, California, United States of America

Competing Interests

Dale Kern and Helen Knaggs are employess of Nuskin. These competing interests do not alter our adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceptualization: JX RCS LG RAF EAT RL IR KQ DK HEK HYC ALSC. Data curation: JX RCS KQ. Formal analysis: JX RCS ALSC HYC LG. Funding acquisition: ALSC. Investigation: JX RCS LG RAF EAT RL IR ALSC. Methodology: JX RCS LG RAF EAT RL IR KQ DK HEK HYC ALSC. Project administration: LG ALSC. Resources: HEK DK ALSC. Software: KQ JX. Supervision: ALSC. Validation: JX. Visualization: ALSC. Writing – original draft: JX RCS LG RAF RL IR HYC ALSC. Writing – review & editing: JX RCS LG RAF EAT RL IR HYC ALSC.