About the Authors

Paulette D. Chandler

pchandler@partners.org (PDC); smora@partners.org (SM)

Affiliation Division of Preventive Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

Akintunde O. Akinkuolie

Affiliations Division of Preventive Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Division of Cardiovascular Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

Deirdre K. Tobias

Affiliations Division of Preventive Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America

Patrick R. Lawler

Affiliations Division of Preventive Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Division of Cardiovascular Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America

Chungying Li

Affiliation Division of Preventive Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

M. Vinayaga Moorthy

Affiliation Division of Preventive Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

Lu Wang

Affiliations Division of Preventive Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America

Daniel A. Duprez

Affiliation Department of Medicine, University of Minnesota, Minneapolis, Minnesota, United States of America

David R. Jacobs

Affiliation Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota, United States of America

Robert J. Glynn

Affiliations Division of Preventive Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America

James Otvos

Affiliation LabCorp, Raleigh, North Carolina, United States of America

Margery A. Connelly

Affiliation LabCorp, Raleigh, North Carolina, United States of America

Wendy S. Post

Affiliations Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States of America

Paul M. Ridker

Affiliations Division of Preventive Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Division of Cardiovascular Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America

JoAnn E. Manson

Affiliations Division of Preventive Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America

Julie E. Buring

Affiliations Division of Preventive Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America

I-Min Lee

Affiliations Division of Preventive Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America

Samia Mora

pchandler@partners.org (PDC); smora@partners.org (SM)

Affiliations Division of Preventive Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Division of Cardiovascular Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

Competing Interests

We have the following interests: Samia Mora 500 has received research support from NHLBI, AstraZeneca, and Atherotech Diagnostics; and served as a consultant to Lilly, Pfizer, and Cerenis Therapeutics. Paul Ridker has received research support from AstraZeneca, Novartis, Roche, and Sanofi-Aventis; Paul Ridker and Brigham and Women’s Hospital have patents for the use of inflammatory biomarkers for cardiovascular disease and diabetes. Margery A. Connolly and James D. Otvos are employees of LabCorp. Provisional Patent Application (Paulette Chandler, Samia Mora, and James Otvos) filed June 3, 2016, entitled “Methods and Systems for Predicting Colorectal Cancer Incidence and Mortality" (patent application serial number 62/345,453). There are no further patents, products in development or marketed products to declare. This does not alter our adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceptualization: PDC AOA DKT PRL IL JEB SM JEM JO WSP RJG LW DRJ DAD MAC PMR. Data curation: CL MVM. Formal analysis: PDC PRL AOA SM MVM CL. Funding acquisition: PDC IL JEB SM JEM JO PMR MAC. Investigation: PDC PRL AOA SM MVM CL JEM PMR IL JEB. Methodology: PDC PRL AOA SM MVM CL PMR DAD WSP DRJ. Project administration: PDC SM JEB MVM JEM. Resources: JO MAC JEB JEM. Supervision: PDC SM AOA JEB. Validation: PDC MVM CL DAD DRJ WSP SM. Visualization: PDC SM AOA MVM CL. Writing – original draft: PDC SM AOA PRL. Writing – review & editing: PDC AOA DKT PRL CL MVM LW DAD DRJ RJG JO MAC WSP PMR JEM JEB IL SM.