About the Authors

Jou-Ku Chung

Contributed equally to this work with: Jou-Ku Chung, Eilish Brown, Bob Crooker, Kathleen J. Palmieri, Thomas G. McCauley

jchung@shire.com

Affiliation Shire, Lexington, Massachusetts, United States of America

Eilish Brown

Contributed equally to this work with: Jou-Ku Chung, Eilish Brown, Bob Crooker, Kathleen J. Palmieri, Thomas G. McCauley

Affiliation Shire, Lexington, Massachusetts, United States of America

Bob Crooker

Contributed equally to this work with: Jou-Ku Chung, Eilish Brown, Bob Crooker, Kathleen J. Palmieri, Thomas G. McCauley

Affiliation Shire, Lexington, Massachusetts, United States of America

Kathleen J. Palmieri

Contributed equally to this work with: Jou-Ku Chung, Eilish Brown, Bob Crooker, Kathleen J. Palmieri, Thomas G. McCauley

Affiliation Shire, Lexington, Massachusetts, United States of America

Thomas G. McCauley

Contributed equally to this work with: Jou-Ku Chung, Eilish Brown, Bob Crooker, Kathleen J. Palmieri, Thomas G. McCauley

Affiliation Shire, Lexington, Massachusetts, United States of America

Competing Interests

I have read the journal's policy and the authors of this manuscript have the following competing interests: This study was funded and conducted by Shire (http://www.shire.com/shireplc/en/home). Editorial assistance was provided by Robin Smith, PhD, of The Curry Rockefeller Group, LLC, Tarrytown, New York and this assistance was funded by Shire. The funders had a role in the study design, data collection and analysis, decision to publish, and preparation of the manuscript. The authors are employees and own stock in Shire. This does not alter our adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceptualization: J-KC TGM. Formal analysis: J-KC EB BC KJP TGM. Investigation: J-KC EB BC TGM. Methodology: J-KC EB BC TGM. Project administration: J-KC TGM. Resources: J-KC EB BC KJP TGM. Supervision: J-KC TGM. Validation: J-KC EB BC KP TGM. Visualization: J-KC EB BC KJP TGM. Writing – original draft: J-KC EB BC KJP TGM. Writing – review & editing: J-KC EB BC KJP TGM.