About the Authors

Bridget Sackey-Aboagye

Affiliations Department of Medicine, Perelman School of Medicine, The University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Cell and Molecular Biology Graduate Group, Perelman School of Medicine, The University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Abby L. Olsen

Affiliation Cell and Molecular Biology Graduate Group, Perelman School of Medicine, The University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Sarmistha M. Mukherjee

Affiliation Department of Physiology, Perelman School of Medicine, The University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Alexander Ventriglia

Affiliation Department of Bioengineering, School of Engineering and Applied Sciences, The University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Yasuyuki Yokosaki

Affiliation Hiroshima University, Hiroshima, Japan

Linda E. Greenbaum

Affiliation Janssen R&D, LLC, Spring House, Pennsylvania, United States of America

Gi Yun Lee

Affiliation Department of Bioengineering, School of Engineering and Applied Sciences, The University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Hani Naga

Affiliation Department of Biology, School of Arts and Sciences, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Rebecca G. Wells

rgwells@mail.med.upenn.edu

Affiliations Department of Medicine, Perelman School of Medicine, The University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Cell and Molecular Biology Graduate Group, Perelman School of Medicine, The University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Competing Interests

LEG is affiliated with Janssen R&D. This does not alter our adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceptualization: RGW. Formal analysis: BS-A RGW. Investigation: BS-A ALO SMM AV GYL HN. Methodology: RGW BS-A YY LEG. Project administration: RGW LEG. Resources: YY LEG. Supervision: RGW. Visualization: BS-A. Writing – original draft: BS-A RGW. Writing – review & editing: BS-A RGW LEG.