About the Authors

Li Zhang

Affiliation State Key Laboratory of Microbial Metabolism, School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China

Jin Wang

Affiliation Institute of Medical Science, Department of Pharmacology and Physiology, School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, China

Aizhang Xu

Affiliation State Key Laboratory of Microbial Metabolism, School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China

Conghao Zhong

Affiliation State Key Laboratory of Microbial Metabolism, School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China

Wuguang Lu

Affiliation Laboratory of Cellular and Molecular Biology, Jiangsu Province Institute of Traditional Chinese Medicine, Nanjing, 210028, Jiangsu, China

Li Deng

Affiliation Shanghai HyCharm Inc., 1 Fute Street East, Bldg. 458, Rm. 518, Shanghai 200131, China

Rongxiu Li

rxli@sjtu.edu.cn

Affiliations State Key Laboratory of Microbial Metabolism, School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China, Engineering Research Center of Cell & Therapeutic Antibody, Ministry of Education; Shanghai 200240, China

Competing Interests

I have read the journal’s policy and the author of this manuscript has the following competing interests: Li Deng is an employee of Shanghai HyCharm Inc. Shanghai HyCharm Inc has patented the methods of immunogen design (number WO2014/183649A1), and planned to develop an optimized version of TNF-α therapeutic vaccine. This does not alter the author’s adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceptualization: LZ AZX RXL. Formal analysis: JW. Funding acquisition: RXL. Investigation: LZ JW CHZ. Methodology: LZ JW AZX CHZ. Project administration: LZ. Resources: WGL. Supervision: RXL. Writing – original draft: LZ. Writing – review & editing: LZ LD RXL.