High-Resolution Identification of Specificity Determining Positions in the LacI Protein Family Using Ensembles of Sub-Sampled Alignments

Roman Sloutsky; Kristen M. Naegle

doi:10.1371/journal.pone.0162579

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Open Access

Peer-reviewed

Research Article

High-Resolution Identification of Specificity Determining Positions in the LacI Protein Family Using Ensembles of Sub-Sampled Alignments

Roman Sloutsky,

Affiliations Biomedical Engineering Department, Washington University in St. Louis, St. Louis, Missouri, 63130, United States of America, Center for Biological Systems Engineering, Washington University in St. Louis, St. Louis, Missouri, 63130, United States of America
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Kristen M. Naegle

* E-mail: knaegle@wustl.edu

Affiliations Biomedical Engineering Department, Washington University in St. Louis, St. Louis, Missouri, 63130, United States of America, Center for Biological Systems Engineering, Washington University in St. Louis, St. Louis, Missouri, 63130, United States of America

http://orcid.org/0000-0001-7146-9592

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High-Resolution Identification of Specificity Determining Positions in the LacI Protein Family Using Ensembles of Sub-Sampled Alignments

Roman Sloutsky,
Kristen M. Naegle

Published: September 28, 2016
https://doi.org/10.1371/journal.pone.0162579

About the Authors

Roman Sloutsky

Affiliations Biomedical Engineering Department, Washington University in St. Louis, St. Louis, Missouri, 63130, United States of America, Center for Biological Systems Engineering, Washington University in St. Louis, St. Louis, Missouri, 63130, United States of America

Kristen M. Naegle

* E-mail: knaegle@wustl.edu

http://orcid.org/0000-0001-7146-9592

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceptualization: RS KMN. Data curation: RS. Formal analysis: RS. Funding acquisition: KMN. Investigation: RS. Methodology: RS. Software: RS. Supervision: KMN. Validation: RS. Visualization: RS. Writing – original draft: RS. Writing – review & editing: RS KMN.

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Sequence alignment
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Multiple alignment calculation
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Allosteric regulation
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Protein structure comparison
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Protein sequencing
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Hydrogen bonding
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Protein structure
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Amino acid sequence analysis
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