About the Authors

Shou-Hui Du

Contributed equally to this work with: Shou-Hui Du, Zhendong Li

Affiliation Department of Biological Sciences, National University of Singapore, Singapore, 117543, Singapore

Zhendong Li

Contributed equally to this work with: Shou-Hui Du, Zhendong Li

Affiliation Department of Biological Sciences, National University of Singapore, Singapore, 117543, Singapore

Can Chen

Affiliation Tessa Therapeutics, Pte Ltd., Singapore, 239351, Singapore

Wee-Kiat Tan

Affiliations Department of Biological Sciences, National University of Singapore, Singapore, 117543, Singapore, Institute of Bioengineering and Nanotechnology, Singapore, 138669, Singapore

Zhixia Chi

Affiliation Department of Biological Sciences, National University of Singapore, Singapore, 117543, Singapore

Timothy Weixin Kwang

Affiliation Tessa Therapeutics, Pte Ltd., Singapore, 239351, Singapore

Xue-Hu Xu

Affiliation Department of Gastrointestinal Surgery, the Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510150, China

Shu Wang

dbsws@nus.edu.sg

Affiliations Department of Biological Sciences, National University of Singapore, Singapore, 117543, Singapore, Institute of Bioengineering and Nanotechnology, Singapore, 138669, Singapore

Competing Interests

Authors CC and TWK are employees of Tessa Therapeutics Pte Ltd. Singapore, a commercial company; author SW received funding from Tessa Therapeutics for this study. There are no patents, products in development or marketed products to declare. This does not alter our adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: SW XHX. Performed the experiments: SHD ZL CC WKT ZC. Analyzed the data: SHD ZL CC WKT ZC TWK. Wrote the paper: SW SHD ZL CC TWK.