About the Authors

William S. DeWitt

Contributed equally to this work with: William S. DeWitt, Paul Lindau, Thomas M. Snyder

Affiliation Adaptive Biotechnologies, Seattle, United States of America

Paul Lindau

Contributed equally to this work with: William S. DeWitt, Paul Lindau, Thomas M. Snyder

Affiliations Fred Hutchinson Cancer Research Center, Seattle, United States of America, University of Washington, Seattle, United States of America

Thomas M. Snyder

Contributed equally to this work with: William S. DeWitt, Paul Lindau, Thomas M. Snyder

Affiliation Adaptive Biotechnologies, Seattle, United States of America

Anna M. Sherwood

Affiliation Adaptive Biotechnologies, Seattle, United States of America

Marissa Vignali

Affiliation Adaptive Biotechnologies, Seattle, United States of America

Christopher S. Carlson

Affiliation Fred Hutchinson Cancer Research Center, Seattle, United States of America

Philip D. Greenberg

Affiliation Fred Hutchinson Cancer Research Center, Seattle, United States of America

Natalie Duerkopp

Affiliation Fred Hutchinson Cancer Research Center, Seattle, United States of America

Ryan O. Emerson

Affiliation Adaptive Biotechnologies, Seattle, United States of America

Harlan S. Robins

hrobins@fredhutch.org

Affiliations Adaptive Biotechnologies, Seattle, United States of America, Fred Hutchinson Cancer Research Center, Seattle, United States of America

Competing Interests

C.S.C. owns stock and receives consulting fees from Adaptive Biotechnologies. W.S.D., T.M.S., A.M.S., M.V., R.O.E., and H.S.R. are employees of Adaptive Biotechnologies with salary and stock options. There are no patents, products in development, or marketed products to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: WSD PL TMS AMS CSC PDG ND ROE HSR. Performed the experiments: PL AMS. Analyzed the data: WSD PL TMS MV ROE. Contributed reagents/materials/analysis tools: HSR. Wrote the paper: WSD PL TMS MV HSR.