High-Resolution Diffusion Tensor Spinal Cord MRI Measures as Biomarkers of Disability Progression in a Rodent Model of Progressive Multiple Sclerosis

Francesca Gilli; Xi Chen; Andrew R. Pachner; Barjor Gimi

doi:10.1371/journal.pone.0160071

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Open Access

Peer-reviewed

Research Article

High-Resolution Diffusion Tensor Spinal Cord MRI Measures as Biomarkers of Disability Progression in a Rodent Model of Progressive Multiple Sclerosis

Francesca Gilli ,

* E-mail: Francesca.Gilli@dartmouth.edu

Affiliation Department of Neurology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, United States of America
⨯
Xi Chen,

Affiliation Department of Radiology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, United States of America
⨯
Andrew R. Pachner,

Affiliation Department of Neurology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, United States of America
⨯
Barjor Gimi

Affiliation Department of Radiology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, United States of America
⨯

High-Resolution Diffusion Tensor Spinal Cord MRI Measures as Biomarkers of Disability Progression in a Rodent Model of Progressive Multiple Sclerosis

Francesca Gilli,
Xi Chen,
Andrew R. Pachner,
Barjor Gimi

Published: July 28, 2016
https://doi.org/10.1371/journal.pone.0160071

About the Authors

Francesca Gilli

* E-mail: Francesca.Gilli@dartmouth.edu

Affiliation Department of Neurology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, United States of America

Xi Chen

Affiliation Department of Radiology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, United States of America

Andrew R. Pachner

Affiliation Department of Neurology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, United States of America

Barjor Gimi

Affiliation Department of Radiology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: FG ARP BG. Performed the experiments: FG XC. Analyzed the data: FG XC ARP BG. Contributed reagents/materials/analysis tools: ARP BG. Wrote the paper: FG XC ARP BG.

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Spinal cord
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Diffusion tensor imaging
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Central nervous system
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Multiple sclerosis
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Magnetic resonance imaging
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Antibodies
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Enzyme-linked immunoassays
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Viral load
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