About the Authors

Stephanie N. Moore

Affiliations Department of Orthopaedics and Rehabilitation, Vanderbilt University Medical Center, Medical Center East, South Tower, Suite 4200, 1215 21th Avenue South, Nashville TN, 37232, United States of America, Department of Pharmacology, Vanderbilt University, 2200 Pierce Ave, Robinson Research Building Nashville, TN, 37232, United States of America

Gregory D. Hawley

Affiliation Department of Orthopaedics and Rehabilitation, Vanderbilt University Medical Center, Medical Center East, South Tower, Suite 4200, 1215 21th Avenue South, Nashville TN, 37232, United States of America

Emily N. Smith

Affiliation Department of Orthopaedics and Rehabilitation, Vanderbilt University Medical Center, Medical Center East, South Tower, Suite 4200, 1215 21th Avenue South, Nashville TN, 37232, United States of America

Nicholas A. Mignemi

Affiliations Department of Orthopaedics and Rehabilitation, Vanderbilt University Medical Center, Medical Center East, South Tower, Suite 4200, 1215 21th Avenue South, Nashville TN, 37232, United States of America, Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, 1161 21st Ave S, Nashville, TN, 37232, United States of America

Rivka C. Ihejirika

Affiliation School of Medicine, Vanderbilt University, 2215 Garland Ave, Light Hall, Room 215, Nashville, TN, 37232, United States of America

Masato Yuasa

Affiliation Department of Orthopaedics and Rehabilitation, Vanderbilt University Medical Center, Medical Center East, South Tower, Suite 4200, 1215 21th Avenue South, Nashville TN, 37232, United States of America

Justin M. M. Cates

Affiliation Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, 1161 21st Ave S, Nashville, TN, 37232, United States of America

Xulei Liu

Affiliation Department of Biostatistics, Vanderbilt University, 2525 West End, Ste 11000, Nashville, TN, 37203, United States of America

Jonathan G. Schoenecker

Jon.schoenecker@vanderbilt.edu

Affiliations Department of Orthopaedics and Rehabilitation, Vanderbilt University Medical Center, Medical Center East, South Tower, Suite 4200, 1215 21th Avenue South, Nashville TN, 37232, United States of America, Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, 1161 21st Ave S, Nashville, TN, 37232, United States of America, Department of Pediatrics, Vanderbilt University Medical Center, 4202 Doctor’s Office Tower, 2200 Children’s Way, Nashville, TN, 37232, United States of America, Department of Pharmacology, Vanderbilt University, 2200 Pierce Ave, Robinson Research Building Nashville, TN, 37232, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SNM GDH ENS NAM RCI XL JGS. Performed the experiments: SNM GDH ENS NAM RCI MY. Analyzed the data: SNM GDH ENS JMMC XL JGS. Contributed reagents/materials/analysis tools: MY XL JGS. Wrote the paper: SNM GDH ENS NAM RCI MY JMMC XL JGS. Participated in blinded radiograph scoring: ENS NAM. Produced radiographic images: SNM GDH ENS NAM MY. Produced Training Videos: SNM GDH.