Cardiomyocyte Circadian Oscillations Are Cell-Autonomous, Amplified by β-Adrenergic Signaling, and Synchronized in Cardiac Ventricle Tissue

Stephen Beesley; Takako Noguchi; David K. Welsh

doi:10.1371/journal.pone.0159618

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Peer-reviewed

Research Article

Cardiomyocyte Circadian Oscillations Are Cell-Autonomous, Amplified by β-Adrenergic Signaling, and Synchronized in Cardiac Ventricle Tissue

Stephen Beesley ,

Contributed equally to this work with: Stephen Beesley, Takako Noguchi

Current address: Department of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, Florida, United States of America

Affiliations Center for Circadian Biology, University of California San Diego, La Jolla, California, United States of America, Department of Psychiatry, University of California San Diego, La Jolla, California, United States of America
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Takako Noguchi ,

Contributed equally to this work with: Stephen Beesley, Takako Noguchi

* E-mail: tnoguchi@ucsd.edu

Affiliations Center for Circadian Biology, University of California San Diego, La Jolla, California, United States of America, Department of Psychiatry, University of California San Diego, La Jolla, California, United States of America
⨯
David K. Welsh

Affiliations Center for Circadian Biology, University of California San Diego, La Jolla, California, United States of America, Department of Psychiatry, University of California San Diego, La Jolla, California, United States of America, Veterans Affairs San Diego Healthcare System, San Diego, California, United States of America
⨯

Cardiomyocyte Circadian Oscillations Are Cell-Autonomous, Amplified by β-Adrenergic Signaling, and Synchronized in Cardiac Ventricle Tissue

Stephen Beesley,
Takako Noguchi,
David K. Welsh

Published: July 26, 2016
https://doi.org/10.1371/journal.pone.0159618

About the Authors

Stephen Beesley

Contributed equally to this work with: Stephen Beesley, Takako Noguchi

Current address: Department of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, Florida, United States of America

Affiliations Center for Circadian Biology, University of California San Diego, La Jolla, California, United States of America, Department of Psychiatry, University of California San Diego, La Jolla, California, United States of America

Takako Noguchi

Contributed equally to this work with: Stephen Beesley, Takako Noguchi

* E-mail: tnoguchi@ucsd.edu

David K. Welsh

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: TN SB DKW. Performed the experiments: SB TN. Analyzed the data: SB TN. Contributed reagents/materials/analysis tools: DKW TN. Wrote the paper: SB TN DKW.

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Circadian rhythms
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Cardiomyocytes
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Circadian oscillators
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Cardiac ventricles
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Heart
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Gene expression
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Isoproterenol
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Heart rate
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