About the Authors

Bonnie K. Harrington

‡ BH and HG are co-first authors and contributed equally to this work. AJ and WK are co-senior authors and contributed equally to this work.

Affiliation Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio, United States of America

Heather L. Gardner

‡ BH and HG are co-first authors and contributed equally to this work. AJ and WK are co-senior authors and contributed equally to this work.

Affiliation Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio, United States of America

Raquel Izumi

Affiliation Acerta Pharma BV, Oss, Netherlands

Ahmed Hamdy

Affiliation Acerta Pharma BV, Oss, Netherlands

Wayne Rothbaum

Affiliation Acerta Pharma BV, Oss, Netherlands

Kevin R. Coombes

Affiliation Department of Biomedical Informatics, College of Medicine, The Ohio State University, Columbus, Ohio, United States of America

Todd Covey

Affiliation Acerta Pharma BV, Oss, Netherlands

Allard Kaptein

Affiliation Acerta Pharma BV, Oss, Netherlands

Michael Gulrajani

Affiliation Acerta Pharma BV, Oss, Netherlands

Bart Van Lith

Affiliation Acerta Pharma BV, Oss, Netherlands

Cecile Krejsa

Affiliation Acerta Pharma BV, Oss, Netherlands

Christopher C. Coss

Affiliation Division of Pharmaceutics and Pharmaceutical Chemistry, College of Pharmacy, The Ohio State University, Columbus, Ohio, United States of America

Duncan S. Russell

Affiliation Department of Biomedical Sciences, College of Veterinary Medicine, Oregon State University, Corvallis, Oregon, United States of America

Xiaoli Zhang

Affiliation Center for Biostatistics, The Ohio State University, Columbus, Ohio, United States of America

Bridget K. Urie

Affiliation Pittsburgh Veterinary Specialty and Emergency Center, Pittsburgh, Pennsylvania, United States of America

Cheryl A. London

Affiliations Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio, United States of America, Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio, United States of America

John C. Byrd

Affiliation Division of Hematology, Department of Internal Medicine, College of Medicine, The Ohio State University, Columbus, Ohio, United States of America

Amy J. Johnson

amy.johnson@osumc.edu (AJ); kisseberth.2@osu.edu (WK)

‡ BH and HG are co-first authors and contributed equally to this work. AJ and WK are co-senior authors and contributed equally to this work.

Affiliation Division of Hematology, Department of Internal Medicine, College of Medicine, The Ohio State University, Columbus, Ohio, United States of America

William C. Kisseberth

amy.johnson@osumc.edu (AJ); kisseberth.2@osu.edu (WK)

‡ BH and HG are co-first authors and contributed equally to this work. AJ and WK are co-senior authors and contributed equally to this work.

Affiliation Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio, United States of America

Competing Interests

Acerta Pharma is a commercial funder. Raquel Izumi, Ahmed Hamdy, Allard Kaptein, Michael Gulrajani, Bart Van Lith, Todd Covey, Wayne Rothbaum, and Cecile Krejsa are employed by Acerta Pharma. This does not alter the authors' adherence to PLOS ONE policies on sharing data and materials. The remaining authors have no conflicts of interest to disclose.

Author Contributions

Conceived and designed the experiments: AJ BH JB WK RI AH AK WR TC MG BVL CK. Performed the experiments: BH HG WK CL BU. Analyzed the data: XZ KC AJ JB BH WK BU CL DR CC. Contributed reagents/materials/analysis tools: AJ JB BH. Wrote the paper: BH.