About the Authors

Sabine Sewing

sabine.sewing@roche.com

Affiliation Roche Pharmaceutical Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Basel, Switzerland

Franziska Boess

Affiliation Roche Pharmaceutical Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Basel, Switzerland

Annie Moisan

Affiliation Roche Pharmaceutical Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Basel, Switzerland

Cristina Bertinetti-Lapatki

Affiliation Roche Pharmaceutical Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Basel, Switzerland

Tanja Minz

Affiliation Roche Pharmaceutical Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Basel, Switzerland

Maj Hedtjaern

Affiliation Roche Pharmaceutical Research and Early Development, Therapeutic Modalities, Roche Innovation Center Copenhagen A/S, Hørsholm, Denmark

Yann Tessier

Affiliation Roche Pharmaceutical Research and Early Development, Therapeutic Modalities, Roche Innovation Center Copenhagen A/S, Hørsholm, Denmark

Franz Schuler

Affiliation Roche Pharmaceutical Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Basel, Switzerland

Thomas Singer

Affiliation Roche Pharmaceutical Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Basel, Switzerland

Adrian B. Roth

Affiliation Roche Pharmaceutical Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Basel, Switzerland

Competing Interests

SS, FB, AM, CBL, TM, MH, YT, FS, TS, and ABR are employees of Roche Innovation Center Basel or Roche Innovation Center Copenhagen A/S, F. Hoffmann-La Roche Ltd. The funder provided support in the form of salaries for authors (SS, FB, AM, CBL, TM, MH, YT, FS, TS, ABR), but did not have any additional role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. SS, FB, AM, CBL and ABR are named inventors on patent application EP16161820.2 entitled “IN VITRO TOXICITY SCREENING ASSAY.” This does not alter the authors’ adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: SS FB AM CBL YT MH FS TS ABR. Performed the experiments: SS AM CBL TM. Analyzed the data: SS AM CBL TM. Contributed reagents/materials/analysis tools: FB YT MH. Wrote the paper: SS ABR.