http://orcid.org/0000-0002-2308-1048
About the Authors
- Felipe de Jesus Cortez
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Affiliation Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California 94158, United States of America
- Miyuki Suzawa
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Affiliation Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, California 94158, United States of America
- Sam Irvy
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Affiliation Chemistry and Chemical Biology Graduate Program, University of California San Francisco, San Francisco, California 94158, United States of America
- John M. Bruning
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Affiliation Pharmaceutical Sciences and Pharmacogenomics Graduate Program, University of California San Francisco, San Francisco, California 94158, United States of America
- Elena Sablin
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Affiliation Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California 94158, United States of America
- Matthew P. Jacobson
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Affiliation Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California 94158, United States of America
- Robert J. Fletterick
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Affiliation Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California 94158, United States of America
- Holly A. Ingraham
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* E-mail: holly.ingraham@ucsf.edu (HAI); pamela.england@ucsf.edu (PME)
Affiliation Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, California 94158, United States of America
- Pamela M. England
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* E-mail: holly.ingraham@ucsf.edu (HAI); pamela.england@ucsf.edu (PME)
Affiliations Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California 94158, United States of America, Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, California 94158, United States of America
Competing Interests
MPJ is a consultant to Schrodinger LLC, which develops and licenses some of the software used in this work. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.
Author Contributions
Conceived and designed the experiments: PME HAI. Performed the experiments: FdJC MS SI JMB. Analyzed the data: PME HAI MS FdJC JMB SI. Contributed reagents/materials/analysis tools: ES RJF MPJ. Wrote the paper: PME HAI.