About the Authors
- Hiroyuki Kimura
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* E-mail: hsaji@pharm.kyoto-u.ac.jp (HS); hkimura@mb.kyoto-phu.ac.jp (HK)
Affiliations Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Kyoto, Japan, Department of Analytical and Bioinorganic Chemistry, Kyoto Pharmaceutical University, Kyoto, Kyoto, Japan
- Kenji Tomatsu
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Affiliation Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Kyoto, Japan
- Hidekazu Saiki
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Affiliation Technology Research Laboratory, Shimadzu Corporation, Souraku-gun, Kyoto, Japan
- Kenji Arimitsu
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Affiliations Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Kyoto, Japan, School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women’s University, Nishinomiya, Hyogo, Japan
- Masahiro Ono
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Affiliation Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Kyoto, Japan
- Hidekazu Kawashima
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Affiliations Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Kyoto, Japan, Radioisotope Research Center, Kyoto Pharmaceutical University, Kyoto, Kyoto, Japan
- Ren Iwata
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Affiliation CYRIC, Tohoku University, Sendai, Miyagi, Japan
- Hiroaki Nakanishi
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Affiliation Technology Research Laboratory, Shimadzu Corporation, Souraku-gun, Kyoto, Japan
- Eiichi Ozeki
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Affiliation Technology Research Laboratory, Shimadzu Corporation, Souraku-gun, Kyoto, Japan
- Yuji Kuge
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Affiliations Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Kyoto, Japan, Central Institute of Isotope Science, Hokkaido University, Sapporo, Hokkaido, Japan
- Hideo Saji
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* E-mail: hsaji@pharm.kyoto-u.ac.jp (HS); hkimura@mb.kyoto-phu.ac.jp (HK)
Affiliation Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Kyoto, Japan
Competing Interests
The authors have declared that no competing interests exist. Shimadzu Corporation does not alter the authors’ adherence to PLOS ONE policies on sharing data and materials.
Author Contributions
Conceived and designed the experiments: H. Kimura RI H. Saji. Performed the experiments: H. Kimura KT KA MO H. Saji. Analyzed the data: H. Kawashima YK. Contributed reagents/materials/analysis tools: H. Saiki RI. Wrote the paper: H. Kimura KT KA MO H. Kawashima H. Saji. Flow simulation: HN EO.