About the Authors

Elena Vigorito

Affiliation Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom

Karoline B. Kuchenbaecker

Affiliation Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom

Jonathan Beesley

Affiliation Department of Genetics, QIMR Berghofer Medical Research Institute, Herston Road, Brisbane, Australia, 4029

Julian Adlard

Affiliation Yorkshire Regional Genetics Service, Chapel Allerton Hospital, Leeds, United Kingdom

Bjarni A. Agnarsson

Affiliation Department of Pathology, University Hospital (Landspitali) and University of Iceland School of Medicine, Hringbraut, 101 Reykjavik, Iceland

Irene L. Andrulis

Affiliation Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada

Banu K. Arun

Affiliation Department of Breast Medical Oncology and Clinical Cancer Genetics Program, University Of Texas MD Anderson Cancer Center, 1515 Pressler Street, CBP 5, Houston, TX, United States of America

Laure Barjhoux

Affiliation Bâtiment Cheney D, Centre Léon Bérard, 28 rue Laënnec, Lyon, France

Muriel Belotti

Affiliation Service de Génétique Oncologique, Institut Curie, 26, rue d’Ulm, Paris Cedex 05, France

Javier Benitez

Affiliation Human Genetics Group, Spanish National Cancer Centre (CNIO), Madrid, Spain, and Human Genotyping (CEGEN) Unit, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), Madrid, Spain

Andreas Berger

Affiliation Dept of OB/GYN, Medical University of Vienna, Vienna, Austria

Anders Bojesen

Affiliation Department of Clinical Genetics, Vejle Hospital, Kabbeltoft 25, Vejle, Denmark

Bernardo Bonanni

Affiliation Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia (IEO), via Ripamonti 435, 20141 Milan, Italy

Carole Brewer

Affiliation Department of Clinical Genetics, Royal Devon & Exeter Hospital, Exeter, United Kingdom

Trinidad Caldes

Affiliation Molecular Oncology Laboratory, Hospital Clinico San Carlos, IdISSC (El Instituto de Investigación Sanitaria del Hospital Clínico San Carlos), Martin Lagos s/n, Madrid, Spain

Maria A. Caligo

Affiliation Section of Genetic Oncology, Dept. of Laboratory Medicine, University and University Hospital of Pisa, Pisa Italy

Ian Campbell

Affiliation Research Division, Peter MacCallum Cancer Centre, Locked Bag 1, A'Beckett Street, Melbourne, VIC 8006, Australia

Salina B. Chan

Affiliation 1600 Divisadero Street, C415, San Francisco, CA 94143–1714, United States of America

Kathleen B. M. Claes

Affiliation Center for Medical Genetics, Ghent University, De Pintelaan 185, 9000 Gent, Belgium

David E. Cohn

Affiliation Ohio State University Columbus Cancer Council GYN Oncology, 3651 Ridge Mill Drive, Columbus, OH 43026, United States of America

Jackie Cook

Affiliation Sheffield Clinical Genetics Service, Sheffield Children’s Hospital, Sheffield, United Kingdom

Mary B. Daly

Affiliation Department of Clinical Oncology, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA, United States of America

Francesca Damiola

Affiliation Bâtiment Cheney D, Centre Léon Bérard, 28 rue Laënnec, Lyon, France

Rosemarie Davidson

Affiliation Department of Clinical Genetics, South Glasgow University Hospitals, Glasgow, United Kingdom

Antoine de Pauw

Affiliation Service de Génétique Oncologique, Institut Curie, 26, rue d’Ulm, Paris Cedex 05, France

Capucine Delnatte

Affiliation Unité d'oncogénétique, ICO-Centre René Gauducheau, Boulevard Jacques Monod, 44805 Nantes Saint Herblain Cedex, France

Orland Diez

Affiliation Oncogenetics Group, Vall d’Hebron University Hospital, Vall d’Hebron Institute of Oncology (VHIO), and Universitat Autònoma, Passeig Vall d'Hebron 119–129, Barcelona, Spain

Susan M. Domchek

Affiliation Department of Medicine, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, 3400 Civic Center Boulevard, Philadelphia, PA 19104, United States of America

Martine Dumont

Affiliation Genomics Center, Centre Hospitalier Universitaire de Québec Research Center and Laval University, 2705 Laurier Boulevard, Quebec City (Quebec), Canada

Katarzyna Durda

Affiliation Department of Genetics and Pathology, Pomeranian Medical University, Polabska 4, Szczecin, Poland

Bernd Dworniczak

Affiliation Institute of Human Genetics, University of Münster, Münster, Germany

Douglas F. Easton

Affiliation Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom

Diana Eccles

Affiliation University of Southampton Faculty of Medicine, Southampton University Hospitals NHS Trust, Southampton, United Kingdom

Christina Edwinsdotter Ardnor

Affiliation Department of Radiation Sciences, Oncology, Umeå University, Umea, Sweden

Ros Eeles

Affiliation Oncogenetics Team, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Sutton, United Kingdom

Bent Ejlertsen

Affiliation Department of Oncology, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, DK-2100 Copenhagen, Denmark

Steve Ellis

Affiliation Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, United Kingdom

D. Gareth Evans

Affiliation Genomic Medicine, Manchester Academic Health Sciences Centre, Institute of Human Development, Manchester University, Central Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom

Lidia Feliubadalo

Affiliation Molecular Diagnostic Unit, Hereditary Cancer Program, IDIBELL (Bellvitge Biomedical Research Institute), Catalan Institute of Oncology, Gran Via de l'Hospitalet, 199–203, 08908 L'Hospitalet, Barcelona, Spain

Florentia Fostira

Affiliation Molecular Diagnostics Laboratory, (INRASTES) Institute of Nuclear and Radiological Sciences and Technology, National Centre for Scientific Research "Demokritos", Patriarchou Gregoriou & Neapoleos str., Aghia Paraskevi, Attiki, Athens, Greece

William D. Foulkes

Affiliation Program in Cancer Genetics, Departments of Human Genetics and Oncology, McGill University, Montreal, Quebec, Canada

Eitan Friedman

Affiliation The Susanne Levy Gertner Oncogenetics Unit, Institute of Human Genetics, Chaim Sheba Medical Center, Ramat Gan 52621, and Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv 69978, Israel

Debra Frost

Affiliation Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, United Kingdom

Pragna Gaddam

Affiliation Clinical Cancer Genetics Laboratory, Memorial Sloane Kettering Cancer Center, New York, NY, United States of America

Patricia A. Ganz

Affiliation UCLA Schools of Medicine and Public Health, Division of Cancer Prevention & Control Research, Jonsson Comprehensive Cancer Center, 650 Charles Young Drive South, Room A2-125 HS, Los Angeles, CA 90095–6900, United States of America

Judy Garber

Affiliation Cancer Risk and Prevention Clinic, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA, United States of America

Vanesa Garcia-Barberan

Affiliation Molecular Oncology Laboratory, Hospital Clinico San Carlos, IdISSC (El Instituto de Investigación Sanitaria del Hospital Clínico San Carlos), Martin Lagos s/n, Madrid, Spain

Marion Gauthier-Villars

Affiliation Service de Génétique Oncologique, Institut Curie, 26, rue d’Ulm, Paris Cedex 05, France

Andrea Gehrig

Affiliation Centre of Familial Breast and Ovarian Cancer, Department of Medical Genetics, Institute of Human Genetics, University Würzburg, Würzburg, Germany

Anne-Marie Gerdes

Affiliation Department of Clinical Genetics, Rigshospitalet 4062, Blegdamsvej 9, København Ø, Denmark

Sophie Giraud

Affiliation Service de Génétique Moléculaire et Clinique, Hospices Civils de Lyon, Lyon cedex 04, France

Andrew K. Godwin

Affiliation Department of Pathology and Laboratory Medicine, 3901 Rainbow Boulevard, 4019 Wahl Hall East, MS 3040, University of Kansas Medical Center, Kansas City, Kansas, United States of America

David E. Goldgar

Affiliation Department of Dermatology, University of Utah School of Medicine, 30 North 1900 East, SOM 4B454, Salt Lake City, UT 84132, United States of America

Christopher R. Hake

Affiliation City of Hope Clinical Cancer Genetics Community Research Network, 1500 East Duarte Road, Duarte, CA 91010, United States of America

Thomas V. O. Hansen

Affiliation Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, DK-2100 Copenhagen, Denmark

Sue Healey

Affiliation Department of Genetics, QIMR Berghofer Medical Research Institute, Herston Road, Brisbane, Australia, 4029

Shirley Hodgson

Affiliation Medical Genetics Unit, St George's, University of London, London, United Kingdom

Frans B. L. Hogervorst

Affiliation Family Cancer Clinic, Netherlands Cancer Institute, P.O. Box 90203, 1000 BE, Amsterdam, The Netherlands

Claude Houdayer

Affiliation Service de Génétique Oncologique, Institut Curie, 26, rue d’Ulm, Paris Cedex 05, France

Peter J. Hulick

Affiliation Center for Medical Genetics, NorthShore University Health System, University of Chicago Pritzker School of Medicine, 1000 Central Street, Suite 620, Evanston, IL 60201, United States of America

Evgeny N. Imyanitov

Affiliation N.N. Petrov Institute of Oncology, St.-Petersburg 197758, Russia

Claudine Isaacs

Affiliation Lombardi Comprehensive Cancer Center, Georgetown University, 3800 Reservoir Road NW, Washington, DC, United States of America

Louise Izatt

Affiliation Clinical Genetics, Guy’s and St. Thomas’ NHS Foundation Trust, London, United Kingdom

Angel Izquierdo

Affiliation Genetic Counseling Unit, Hereditary Cancer Program, IDIBGI (Institut d'Investigació Biomèdica de Girona), Catalan Institute of Oncology, Av. França s/n. 1707 Girona, Spain

Lauren Jacobs

Affiliation Clinical Genetics Research Laboratory, Dept. of Medicine, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY, United States of America

Anna Jakubowska

Affiliation Department of Genetics and Pathology, Pomeranian Medical University, Polabska 4, Szczecin, Poland

Ramunas Janavicius

Affiliation Vilnius University Hospital Santariskiu Clinics, Hematology, oncology and transfusion medicine center, Dept. of Molecular and Regenerative Medicine, Santariskiu st., State Research Institute Centre for Innovative medicine, Zygymantu st. 9, Vilnius, Lithuania

Katarzyna Jaworska-Bieniek

Affiliation Department of Genetics and Pathology, Pomeranian Medical University, Polabska 4, Szczecin, Poland

Uffe Birk Jensen

Affiliation Department of Clinical Genetics, Aarhus University Hospital, Brendstrupgaardsvej 21C, Aarhus N, Denmark

Esther M. John

Affiliation Department of Epidemiology, Cancer Prevention Institute of California, 2201 Walnut Avenue, Suite 300, Fremont, CA 94538, United States of America

Joseph Vijai

Affiliation Clinical Genetics Research Laboratory, Dept. of Medicine, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10044, United States of America

Beth Y. Karlan

Affiliation Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Suite 290W, Los Angeles, CA, United States of America

Karin Kast

Affiliation Department of Gynaecology and Obstetrics, University Hospital Carl Gustav Carus, Technical University Dresden, Dresden, Germany

KConFab Investigators

Affiliation Kathleen Cuningham Consortium for Research into Familial Breast Cancer, Peter MacCallum Cancer Center, Melbourne, Australia

Sofia Khan

Affiliation Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Biomedicum Helsinki, P.O. BOX 700 (Haartmaninkatu 8), 00029 HUS, Finland

Ava Kwong

Affiliation The Hong Kong Hereditary Breast Cancer Family Registry, Cancer Genetics Center, Hong Kong Sanatorium and Hospital, Hong Kong China

Yael Laitman

Affiliation The Susanne Levy Gertner Oncogenetics Unit, Institute of Human Genetics, Chaim Sheba Medical Center, Ramat Gan 52621, Israel

Jenny Lester

Affiliation Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Suite 290W, Los Angeles, CA, United States of America

Fabienne Lesueur

Affiliation Genetic Epidemiology of Cancer team, Inserm U900, Institut Curie, Mines ParisTech, 26 rue d'Ulm, 75248 Paris cedex 05, France

Annelie Liljegren

Affiliation Department of Oncology, Karolinska University Hospital, Stockholm, Sweden

Jan Lubinski

Affiliation Department of Genetics and Pathology, Pomeranian Medical University, Polabska 4, Szczecin, Poland

Phuong L. Mai

Affiliation Clinical Genetics Branch, DCEG, NCI, NIH, 9609 Medical Center Drive, Room 6E-454, Bethesda, MD, United States of America

Siranoush Manoukian

Affiliation Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale Tumori (INT), Via Giacomo Venezian 1, 20133 Milan, Italy

Sylvie Mazoyer

Affiliation Bâtiment Cheney D, Centre Léon Bérard, 28 rue Laënnec, Lyon, France

Alfons Meindl

Affiliation Department of Gynaecology and Obstetrics, Division of Tumor Genetics, Klinikum rechts der Isar, Technical University Munich, Munich, Germany

Arjen R. Mensenkamp

Affiliation Department of Human Genetics, Radboud university medical centre, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands

Marco Montagna

Affiliation Immunology and Molecular Oncology Unit, Veneto Institute of Oncology IOV—IRCCS, Via Gattamelata 64, Padua, Italy

Katherine L. Nathanson

Affiliation Department of Medicine, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, 3400 Civic Center Boulevard, Philadelphia, PA 19104, United States of America

Susan L. Neuhausen

Affiliation Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, CA, United States of America

Heli Nevanlinna

Affiliation Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Biomedicum Helsinki, P.O. BOX 700 (Haartmaninkatu 8), 00029 HUS, Finland

Dieter Niederacher

Affiliation Department of Gynaecology and Obstetrics, University Hospital Düsseldorf, Heinrich-Heine University Düsseldorf, Düsseldorf, Germany

Edith Olah

Affiliation Department of Molecular Genetics, National Institute of Oncology, Budapest, Hungary

Olufunmilayo I. Olopade

Affiliation The University of Chicago Medicine, 5841 South Maryland Avenue, MC 2115 Chicago, IL 60637

Kai-ren Ong

Affiliation West Midlands Regional Genetics Service, Birmingham Women’s Hospital Healthcare NHS Trust, Edgbaston, Birmingham, United Kingdom

Ana Osorio

Affiliation Human Genetics Group, Spanish National Cancer Centre (CNIO), Madrid, Spain

Sue Kyung Park

Affiliation Department of Preventive Medicine, Seoul National University College of Medicine, Department of Biomedical Science, Seoul National University Graduate School, and Cancer Research Institute, Seoul National University, 103 Daehak-ro, Jongno-gu, Seoul 110–799, Korea

Ylva Paulsson-Karlsson

Affiliation Department of Immunology, Genetics and Pathology, Uppsala University, SE-751 85 Uppsala, Sweden

Inge Sokilde Pedersen

Affiliation Section of Molecular Diagnostics, Department of Biochemistry, Aalborg University Hospital, Reberbansgade 15, Aalborg, Denmark

Bernard Peissel

Affiliation Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale Tumori (INT), Via Giacomo Venezian 1, 20133 Milan, Italy

Paolo Peterlongo

Affiliation IFOM, The FIRC (Italian Foundation for Cancer Research) Institute of Molecular Oncology, c/o IFOM-IEO campus, via Adamello 16, 20139 Milan, Italy

Georg Pfeiler

Affiliation Medical University of Vienna, Währinger Gürtel 18–20, 1090 Vienna, Austria

Catherine M. Phelan

Affiliation Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida, United States of America

Marion Piedmonte

Affiliation NRG Oncology, Statistics and Data Management Center, Roswell Park Cancer Institute, Elm St & Carlton St, Buffalo, NY 14263, United States of America

Bruce Poppe

Affiliation Center for Medical Genetics, Ghent University, De Pintelaan 185, 9000 Gent, Belgium

Miquel Angel Pujana

Affiliation Translational Research Laboratory, IDIBELL (Bellvitge Biomedical Research Institute), Catalan Institute of Oncology, Barcelona, Spain

Paolo Radice

Affiliation Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predicted Medicine, Fondazione IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale Tumori (INT), c/o Amaedeolab, via GA Amadeo 42, 20133 Milan, Italy

Gad Rennert

Affiliation Clalit National Israeli Cancer Control Center and Department of Community Medicine and Epidemiology, Carmel Medical Center and B. Rappaport Faculty of Medicine, 7 Michal St., Haifa 34362, Israel

Gustavo C. Rodriguez

Affiliation Division of Gynecologic Oncology, NorthShore University HealthSystem, Univ of Chicago, 2650 Ridge Avenue Suite 1507 Walgreens, Evanston, IL 60201, United States of America

Matti A. Rookus

Affiliation Department of Epidemiology, Netherlands Cancer Institute, P.O. Box 90203, 1000 BE, Amsterdam, The Netherlands

Eric A. Ross

Affiliation Biostatistics and Bioinformatics Facility, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, United States of America

Rita Katharina Schmutzler

Affiliation Center for Hereditary Breast and Ovarian Cancer, Medical Faculty, University Hospital Cologne, Cologne, Germany

Jacques Simard

Affiliation Genomics Center, Centre Hospitalier Universitaire de Québec Research Center and Laval University, 2705 Laurier Boulevard, Quebec City (Quebec), Canada

Christian F. Singer

Affiliation Dept of OB/GYN, Medical University of Vienna, Vienna, Austria, and Waehringer Guertel 18–20, A 1090 Vienna, Austria

Thomas P. Slavin

Affiliation Clinical Cancer Genetics, City of Hope, 1500 East Duarte Road, Duarte, California 91010, United States of America

Penny Soucy

Affiliation Genomics Center, Centre Hospitalier Universitaire de Québec Research Center and Laval University, 2705 Laurier Boulevard, Quebec City (Quebec), Canada

Melissa Southey

Affiliation Genetic Epidemiology Laboratory, Department of Pathology, University of Melbourne, Parkville, Victoria, Australia

Doris Steinemann

Affiliation Institute of Cell and Molecular Pathology, Hannover Medical School, Hannover, Germany

Dominique Stoppa-Lyonnet

Affiliation Service de Génétique Oncologique, Institut Curie, 26, rue d’Ulm, Paris Cedex 05, France

Grzegorz Sukiennicki

Affiliation Department of Genetics and Pathology, Pomeranian Medical University, Polabska 4, Szczecin, Poland

Christian Sutter

Affiliation Institute of Human Genetics, Department of Human Genetics, University Hospital Heidelberg, Heidelberg, Germany

Csilla I. Szabo

Affiliation National Human Genome Research Institute, National Institutes of Health, Building 50, Room 5312, 50 South Drive, MSC 004, Bethesda, MD 20892–8004, United States of America

Muy-Kheng Tea

Affiliation Dept of OB/GYN, Medical University of Vienna, Vienna, Austria, and Waehringer Guertel 18–20, A 1090 Vienna, Austria

Manuel R. Teixeira

Affiliation Department of Genetics, Portuguese Oncology Institute, Rua Dr. António Bernardino de Almeida, 4200–072 Porto, Portugal

Soo-Hwang Teo

Affiliation Cancer Research Initiatives Foundation, Sime Darby Medical Centre, 1 Jalan SS12/1A, Subang Jaya, 47500 Malaysia

Mary Beth Terry

Affiliation Department of Epidemiology, Columbia University, New York, NY, United States of America

Mads Thomassen

Affiliation Department of Clinical Genetics, Odense University Hospital, Sonder Boulevard 29, Odense C, Denmark

Maria Grazia Tibiletti

Affiliation UO Anatomia Patologica, Ospedale di Circolo-Università dell'Insubria, Via O.Rossi 9, 21100 Varese, Italy

Laima Tihomirova

Affiliation Latvian Biomedical Research and Study Centre, Ratsupites str 1, Riga, Latvia

Silvia Tognazzo

Affiliation Immunology and Molecular Oncology Unit, Veneto Institute of Oncology IOV—IRCCS, Via Gattamelata 64, Padua, Italy

Elizabeth J. van Rensburg

Affiliation Cancer Genetics Laboratory, Department of Genetics, University of Pretoria, Private Bag X323, Arcadia 0007, South Africa

Liliana Varesco

Affiliation Unit of Hereditary Cancer, Department of Epidemiology, Prevention and Special Functions, IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) AOU San Martino—IST Istituto Nazionale per la Ricerca sul Cancro, largo Rosanna Benzi 10, 16132 Genoa, Italy

Raymonda Varon-Mateeva

Affiliation Institute of Human Genetics, Campus Virchov Klinikum, Charite Berlin, Berlin, Germany

Athanassios Vratimos

Affiliation Molecular Diagnostics Laboratory, (INRASTES) Institute of Nuclear and Radiological Sciences and Technology, National Centre for Scientific Research "Demokritos" Patriarchou Gregoriou & Neapoleos str., Aghia Paraskevi, Attiki, Athens, Greece

Jeffrey N. Weitzel

Affiliation Clinical Cancer Genetics, City of Hope, 1500 East Duarte Road, Duarte, California 91010, United States of America

Lesley McGuffog

Affiliation Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom

Judy Kirk

Affiliation Westmead Hospital, Familial Cancer Service, Hawkesbury Road, P.O. Box 533, Wentworthville, NSW 2145, Australia

Amanda Ewart Toland

Affiliation Divison of Human Cancer Genetics, Departments of Internal Medicine and Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, The Ohio State University, 998 Biomedical Research Tower, Columbus, OH, United States of America

Ute Hamann

Affiliation Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 580, 69120 Heidelberg, Germany

Noralane Lindor

Affiliation Department of Health Sciences Research, Mayo Clinic, 13400 E. Scottsdale Blvd., Scottsdale, AZ, United States of America

Susan J. Ramus

Affiliation Department of Preventive Medicine, Keck School of Medicine, University of Southern California, California, United States of America

Mark H. Greene

Affiliation Clinical Genetics Branch, DCEG, NCI, NIH, 9609 Medical Center Drive, Room 6E-454, Bethesda, MD, United States of America

Fergus J. Couch

Affiliation Department of Laboratory Medicine and Pathology, and Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, Minnesota, United States of America

Kenneth Offit

Affiliation Clinical Genetics Research Laboratory, Dept. of Medicine, Cancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10044, United States of America

Paul D. P. Pharoah

Affiliation Department of Oncology, University of Cambridge, Cambridge, United Kingdom

Georgia Chenevix-Trench

Affiliation Department of Genetics, QIMR Berghofer Medical Research Institute, Herston Road, Brisbane, Australia, 4029

Antonis C. Antoniou

antonis@srl.cam.ac.uk

Affiliation Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Analyzed the data: EV KBK ACA GCT SJR J. Beesley. Contributed reagents/materials/analysis tools: EV KBK J. Beesley JA BAA ILA BKA LB MB J. Benitez A. Berger A. Bojesen BB CB TC MAC IC SBC KBMC DEC JC MBD FD RD AdP CD OD SMD MD KD BD DFE DE CEA RE BE SE DGE LF FF WDF EF DF PG PAG JG VGB MGV AG AMG SG AKG DEG CRH TVOH S. Healey S. Hodgson FBLH CH PJH ENI CI LI AI LJ AJ RJ KJB UBJ EMJ JV BYK KK KConFab Investigators SK AK YL J. Lester FL AL J. Lubinski PLM S. Manoukian S. Mazoyer AM ARM MM KLN SLN HN DN EO OIO KrO AO SKP YPK ISP B. Peissel PP GP CMP MP B. Poppe MAP PR GR GCR MAR EAR RKS JS CFS TPS PS MS DS DSL GS CS CIS MKT MRT SHT MBT MT MGT LT ST EJvR LV RVM AV JNW LM JK AET UH NL SJR MHG FJC KO PDPP GCT ACA. Wrote the paper: EV KBK ACA GCT SJR J. Beesley. Supervised Initiated and coordinated CIMBA: GCT: Conceived and coordinated the synthesis of the iCOGS array: DFE. Coordinated iCOGS genotyping: KO FJC. CIMBA database management: LM.