About the Authors

Amanda L. Tatler

Amanda.tatler@nottingham.ac.uk

Affiliation Division of Respiratory Medicine–City, University of Nottingham, Nottingham, United Kingdom

Amanda T. Goodwin

Affiliation Division of Respiratory Medicine–City, University of Nottingham, Nottingham, United Kingdom

Olumide Gbolahan

Affiliation Division of Respiratory Medicine–City, University of Nottingham, Nottingham, United Kingdom

Gauri Saini

Affiliation Division of Respiratory Medicine–City, University of Nottingham, Nottingham, United Kingdom

Joanne Porte

Affiliation Division of Respiratory Medicine–City, University of Nottingham, Nottingham, United Kingdom

Alison E. John

Affiliation Division of Respiratory Medicine–City, University of Nottingham, Nottingham, United Kingdom

Rachel L. Clifford

Affiliation Division of Respiratory Medicine–City, University of Nottingham, Nottingham, United Kingdom

Shelia M. Violette

Affiliation Biogen, Cambridge, Massachusetts, United States of America

Paul H. Weinreb

Affiliation Biogen, Cambridge, Massachusetts, United States of America

Helen Parfrey

Affiliation Department of Pathology, University of Cambridge, Cambridge, United Kingdom

Paul J. Wolters

Affiliation School of Medicine, University of California San Francisco, San Francisco, California, United States of America

Jack Gauldie

Affiliation Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Canada

Martin Kolb

Affiliation Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Canada

Gisli Jenkins

Affiliation Division of Respiratory Medicine–City, University of Nottingham, Nottingham, United Kingdom

Competing Interests

SMV and PHW are employees of Biogen Idec. This does not alter our adherence to PLOS One policies on sharing data and materials. GJ has Sponsored Research Agreements with GlaxoSmithKline, Novartis and Biogen Idec, has performed consultancy for InterMune, MedImmune, Boehringer Ingelheim, Biogen Idec and Pulmatrix, and has received speakers' fees from Boehringer Ingelheim, MedImmune and Roche. All non-commercially available materials described in the manuscript will be able available on request subject to a material transfer agreement between both parties.

Author Contributions

Conceived and designed the experiments: ALT AG JG MK GJ. Performed the experiments: ALT AG OG GS JP AEJ RLC. Analyzed the data: ALT AG OG GJ. Contributed reagents/materials/analysis tools: SMV PHW PJW JG MK HP. Wrote the paper: ALT AG JP SMV MK GJ HP.