About the Authors

Eleanor C. Law

Affiliation Department of Statistics, University of Oxford, Oxford, United Kingdom

Henry R. Wilman

Affiliation Department of Statistics, University of Oxford, Oxford, United Kingdom

Sebastian Kelm

Affiliation Department of Informatics, UCB Pharma, Slough, United Kingdom

Jiye Shi

Affiliations Department of Informatics, UCB Pharma, Slough, United Kingdom, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, China

Charlotte M. Deane

deane@stats.ox.ac.uk

Affiliation Department of Statistics, University of Oxford, Oxford, United Kingdom

Competing Interests

SK and JS are employed by UCB Pharma. This does not alter the authors’ adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: ECL HRW SK JS CMD. Performed the experiments: ECL HRW. Analyzed the data: ECL HRW CMD. Contributed reagents/materials/analysis tools: HRW SK. Wrote the paper: ECL HRW CMD.