The Spatiotemporal Pattern of Glis3 Expression Indicates a Regulatory Function in Bipotent and Endocrine Progenitors during Early Pancreatic Development and in Beta, PP and Ductal Cells

Hong Soon Kang; Yukimasa Takeda; Kilsoo Jeon; Anton M. Jetten

doi:10.1371/journal.pone.0157138

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Open Access

Peer-reviewed

Research Article

The Spatiotemporal Pattern of Glis3 Expression Indicates a Regulatory Function in Bipotent and Endocrine Progenitors during Early Pancreatic Development and in Beta, PP and Ductal Cells

Hong Soon Kang,

Affiliation Cell Biology Group, Immunity, Inflammation, and Disease Laboratory, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, 27709, NC, United States of America
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Yukimasa Takeda,

Affiliation Cell Biology Group, Immunity, Inflammation, and Disease Laboratory, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, 27709, NC, United States of America
⨯
Kilsoo Jeon,

Affiliation Cell Biology Group, Immunity, Inflammation, and Disease Laboratory, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, 27709, NC, United States of America
⨯
Anton M. Jetten

* E-mail: jetten@niehs.nih.gov

Affiliation Cell Biology Group, Immunity, Inflammation, and Disease Laboratory, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, 27709, NC, United States of America
⨯

The Spatiotemporal Pattern of Glis3 Expression Indicates a Regulatory Function in Bipotent and Endocrine Progenitors during Early Pancreatic Development and in Beta, PP and Ductal Cells

Hong Soon Kang,
Yukimasa Takeda,
Kilsoo Jeon,
Anton M. Jetten

Published: June 7, 2016
https://doi.org/10.1371/journal.pone.0157138

About the Authors

Hong Soon Kang

Affiliation Cell Biology Group, Immunity, Inflammation, and Disease Laboratory, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, 27709, NC, United States of America

Yukimasa Takeda

Kilsoo Jeon

Anton M. Jetten

* E-mail: jetten@niehs.nih.gov

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: HSK AMJ. Performed the experiments: HSK YT KJ. Analyzed the data: HSK YT KJ AMJ. Contributed reagents/materials/analysis tools: YT KJ. Wrote the paper: HSK AMJ.

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Pancreas
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Pancreas development
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Protein expression
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Insulin
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DAPI staining
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Gene expression
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Pancreatic ducts
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Transcription factors
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