About the Authors

Nicole Eckart

Affiliation McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University, Baltimore, MD 21205, United States of America

Qifeng Song

Affiliation Pharmacology and Molecular Sciences, Johns Hopkins University, Baltimore, MD 21205, United States of America

Rebecca Yang

Affiliation Psychiatry and Behavioral Sciences, Johns Hopkins Medicine, Baltimore, MD 21205, United States of America

Ruihua Wang

Affiliation McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University, Baltimore, MD 21205, United States of America

Heng Zhu

Affiliation Pharmacology and Molecular Sciences, Johns Hopkins University, Baltimore, MD 21205, United States of America

Andrew S. McCallion

Affiliation McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University, Baltimore, MD 21205, United States of America

Dimitrios Avramopoulos

adimitr1@jhmi.edu

Affiliations McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University, Baltimore, MD 21205, United States of America, Psychiatry and Behavioral Sciences, Johns Hopkins Medicine, Baltimore, MD 21205, United States of America

Competing Interests

Dr. Avramopoulos is a paid consultant for the pharmaceutical company Ono Pharma USA Inc. This does not alter the authors' adherence to PLOS ONE policies on sharing data and materials. There are no other conflicts of interest.

Author Contributions

Conceived and designed the experiments: DA ASM NE QS HZ. Performed the experiments: NE RY RW. Analyzed the data: NE DA. Contributed reagents/materials/analysis tools: QS HZ ASM DA RW NE. Wrote the paper: NE DA ASM.