About the Authors

Leonard D. Goldstein

goldstein.leonard@gene.com

Affiliations Department of Bioinformatics and Computational Biology, Genentech Inc., South San Francisco, CA, United States of America, Department of Molecular Biology, Genentech Inc., South San Francisco, CA, United States of America

Yi Cao

Affiliation Department of Bioinformatics and Computational Biology, Genentech Inc., South San Francisco, CA, United States of America

Gregoire Pau

Affiliation Department of Bioinformatics and Computational Biology, Genentech Inc., South San Francisco, CA, United States of America

Michael Lawrence

Affiliation Department of Bioinformatics and Computational Biology, Genentech Inc., South San Francisco, CA, United States of America

Thomas D. Wu

Affiliation Department of Bioinformatics and Computational Biology, Genentech Inc., South San Francisco, CA, United States of America

Somasekar Seshagiri

Affiliation Department of Molecular Biology, Genentech Inc., South San Francisco, CA, United States of America

Robert Gentleman

Current address: 23andMe Inc., Mountain View, CA, United States of America

Affiliation Department of Bioinformatics and Computational Biology, Genentech Inc., South San Francisco, CA, United States of America

Competing Interests

The authors of this manuscript have read the journal’s policy and have the following competing interests: All authors are or have been employees of Genentech Inc. and some hold shares in Roche. RG is an employee of 23AndMe Inc. This does not alter the authors’ adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: LDG RG. Analyzed the data: LDG RG. Wrote the paper: LDG RG. Provided advice on method and software development: GP ML TDW. Performed RT-PCR experiments: YC. Provided advice and oversaw sequencing experiments: SS.