About the Authors

Hyun Jeong Kwak

‡ These authors are joint first authors on this work.

Affiliation Department of Pharmacology, Gachon University School of Medicine, Incheon, Republic of Korea

Hye-Eun Choi

‡ These authors are joint first authors on this work.

Affiliation Department of Pharmacology, Gachon University School of Medicine, Incheon, Republic of Korea

Jinsun Jang

Affiliation Department of Pharmacology, Gachon University School of Medicine, Incheon, Republic of Korea

Soo Kyoung Park

Affiliation Department of Pharmacology, Gachon University School of Medicine, Incheon, Republic of Korea

Byoung Heon Cho

Affiliation Natural Substance Research Team, Pharmaceutical R&D center, Kolmar Korea Co. Ltd., Sejong, Republic of Korea

Seul Ki Kim

Affiliation Natural Substance Research Team, Pharmaceutical R&D center, Kolmar Korea Co. Ltd., Sejong, Republic of Korea

Sunyi Lee

Affiliation Department of Systems Biology, Sookmyung Women’s University, Seoul, Republic of Korea

Nam Sook Kang

Affiliation Graduate School of New Drug Discovery and Development, Chungnam National University, Daejeon, Republic of Korea

Hyae Gyeong Cheon

hgcheon@gachon.ac.kr

Affiliations Department of Pharmacology, Gachon University School of Medicine, Incheon, Republic of Korea, Gachon Medical Research Institute, Gil Medical Center, Incheon, Republic of Korea

Competing Interests

BH Choi and SK Kim are employed by Kolmar Korea Co. Ltd. The commercial affiliation (Kolmar Korea Co. Ltd) does not alter the authors' adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: HGC. Performed the experiments: HJK HEC JJ SKP NSK. Analyzed the data: HJK HEC HGC. Contributed reagents/materials/analysis tools: BHC SKK SL. Wrote the paper: HJK HGC.