About the Authors

Iris E. Allijn

i.e.allijn@utwente.nl

Affiliation Department of Biomaterials Science and Technology, University of Twente, Enschede, The Netherlands

Stefan F. C. Vaessen

Affiliation Technology & Innovation, Innovative testing in Life Sciences and Chemistry, University of Applied Sciences Utrecht, Utrecht, The Netherlands

Linda C. Quarles van Ufford

Affiliation Medicinal Chemistry & Chemical Biology – Biomolecular Analysis, Department of Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands

Kees J. Beukelman

Affiliations Medicinal Chemistry & Chemical Biology – Biomolecular Analysis, Department of Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands, PhytoGeniX BV, Bunnik, The Netherlands

Menno P. J. de Winther

Affiliation Department of Medical Biochemistry, Academic Medical Center, Amsterdam, The Netherlands

Gert Storm

Affiliations Department of Biomaterials Science and Technology, University of Twente, Enschede, The Netherlands, Department of Pharmaceutics, Utrecht University, Utrecht, The Netherlands

Raymond M. Schiffelers

Affiliation Clinical Chemistry and Haematology, University Medical Centre, Utrecht, The Netherlands

Competing Interests

KJB is an employee and shareholder of PhytoGenix BV. This does not alter the authors' adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: IEA RMS MPJW SFCV LCQ. Performed the experiments: IEA SFCV RMS. Analyzed the data: IEA. Contributed reagents/materials/analysis tools: KJB MPJW. Wrote the paper: IEA RMS GS. Advice: KJB GS.