Inhibition of Phospho-S6 Kinase, a Protein Involved in the Compensatory Adaptive Response, Increases the Efficacy of Paclitaxel in Reducing the Viability of Matrix-Attached Ovarian Cancer Cells

Jeong In Choi; Sang Hi Park; Hee-Jin Lee; Dae Woo Lee; Hae Nam Lee

doi:10.1371/journal.pone.0155052

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Peer-reviewed

Research Article

Inhibition of Phospho-S6 Kinase, a Protein Involved in the Compensatory Adaptive Response, Increases the Efficacy of Paclitaxel in Reducing the Viability of Matrix-Attached Ovarian Cancer Cells

Jeong In Choi,

Affiliation Department of Obstetrics and Gynecology, Bucheon St. Mary’s Hospital, College of Medicine, Catholic University of Korea, Seoul, Republic of Korea
⨯
Sang Hi Park,

Affiliation Clinical Medicine Research Institute, Bucheon St. Mary’s Hospital, College of Medicine, Catholic University of Korea, Seoul, Republic of Korea
⨯
Hee-Jin Lee,

Affiliation Clinical Medicine Research Institute, Bucheon St. Mary’s Hospital, College of Medicine, Catholic University of Korea, Seoul, Republic of Korea
⨯
Dae Woo Lee,

Affiliation Department of Obstetrics and Gynecology, Bucheon St. Mary’s Hospital, College of Medicine, Catholic University of Korea, Seoul, Republic of Korea
⨯
Hae Nam Lee

* E-mail: leehaenam@catholic.ac.kr

Affiliation Department of Obstetrics and Gynecology, Bucheon St. Mary’s Hospital, College of Medicine, Catholic University of Korea, Seoul, Republic of Korea
⨯

Inhibition of Phospho-S6 Kinase, a Protein Involved in the Compensatory Adaptive Response, Increases the Efficacy of Paclitaxel in Reducing the Viability of Matrix-Attached Ovarian Cancer Cells

Jeong In Choi,
Sang Hi Park,
Hee-Jin Lee,
Dae Woo Lee,
Hae Nam Lee

Published: May 5, 2016
https://doi.org/10.1371/journal.pone.0155052

About the Authors

Jeong In Choi

Affiliation Department of Obstetrics and Gynecology, Bucheon St. Mary’s Hospital, College of Medicine, Catholic University of Korea, Seoul, Republic of Korea

Sang Hi Park

Affiliation Clinical Medicine Research Institute, Bucheon St. Mary’s Hospital, College of Medicine, Catholic University of Korea, Seoul, Republic of Korea

Hee-Jin Lee

Affiliation Clinical Medicine Research Institute, Bucheon St. Mary’s Hospital, College of Medicine, Catholic University of Korea, Seoul, Republic of Korea

Dae Woo Lee

Affiliation Department of Obstetrics and Gynecology, Bucheon St. Mary’s Hospital, College of Medicine, Catholic University of Korea, Seoul, Republic of Korea

Hae Nam Lee

* E-mail: leehaenam@catholic.ac.kr

Affiliation Department of Obstetrics and Gynecology, Bucheon St. Mary’s Hospital, College of Medicine, Catholic University of Korea, Seoul, Republic of Korea

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: HNL. Performed the experiments: SHP HJL HNL. Analyzed the data: JIC SHP HJL DWL HNL. Contributed reagents/materials/analysis tools: SHP HJL DWL HNL. Wrote the paper: JIC HNL.

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Ovarian cancer
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Cancer treatment
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Cell cultures
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Protein expression
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Drug therapy
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Prostate cancer
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Non-small cell lung cancer
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Signal inhibition
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