Alendronate Sodium as Enteric Coated Solid Lipid Nanoparticles; Preparation, Optimization, and In Vivo Evaluation to Enhance Its Oral Bioavailability

Khaled Mohamed Hosny

doi:10.1371/journal.pone.0154926

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Open Access

Peer-reviewed

Research Article

Alendronate Sodium as Enteric Coated Solid Lipid Nanoparticles; Preparation, Optimization, and In Vivo Evaluation to Enhance Its Oral Bioavailability

Khaled Mohamed Hosny

* E-mail: Elswaify2000@yahoo.com; kmhomar@kau.edu.sa

Affiliations Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia, Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Beni Suef University, Beni Suef, Egypt
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Alendronate Sodium as Enteric Coated Solid Lipid Nanoparticles; Preparation, Optimization, and In Vivo Evaluation to Enhance Its Oral Bioavailability

Khaled Mohamed Hosny

Published: May 5, 2016
https://doi.org/10.1371/journal.pone.0154926

About the Authors

Khaled Mohamed Hosny

* E-mail: Elswaify2000@yahoo.com; kmhomar@kau.edu.sa

Affiliations Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia, Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Beni Suef University, Beni Suef, Egypt

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: KMH. Performed the experiments: KMH. Analyzed the data: KMH. Contributed reagents/materials/analysis tools: KMH. Wrote the paper: KMH.

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Lipids
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Nanoparticles
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Surfactants
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Sonication
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Adverse reactions
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Pharmacokinetics
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Drug delivery
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Rabbits
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