About the Authors

Florian Holtbernd

Current address: Department of Neurology, RWTH Aachen University, Aachen, Germany

Affiliation Center for Neurosciences, The Feinstein Institute for Medical Research, Manhasset, New York, United States of America

Chris C. Tang

Affiliation Center for Neurosciences, The Feinstein Institute for Medical Research, Manhasset, New York, United States of America

Andrew Feigin

Affiliations Center for Neurosciences, The Feinstein Institute for Medical Research, Manhasset, New York, United States of America, Department of Neurology, Northwell Health, Manhasset, New York, United States of America

Vijay Dhawan

Affiliation Center for Neurosciences, The Feinstein Institute for Medical Research, Manhasset, New York, United States of America

Maria Felice Ghilardi

Affiliation Department of Physiology, Pharmacology, and Neuroscience, City University of New York Medical School, New York, New York, United States of America

Jane S. Paulsen

Affiliation Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, Iowa, United States of America

Mark Guttman

Affiliation Department of Neurology, University of Toronto, Toronto, Ontario, Canada

David Eidelberg

david1@nshs.edu

Affiliations Center for Neurosciences, The Feinstein Institute for Medical Research, Manhasset, New York, United States of America, Department of Neurology, Northwell Health, Manhasset, New York, United States of America

Competing Interests

The authors of this manuscript have the following competing interests: Dr. David Eidelberg has received consultant fees from Pfizer, Inc. Dr. Mark Guttman has equity in NeuroDerm and has received research funding from Merck for a clinical trial in Parkinson’s disease. The other co-authors have no conflict of interest to disclose. These competing interests do not alter the authors' adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: AF MFG DE. Performed the experiments: AF VD MFG. Analyzed the data: FH CCT DE. Wrote the paper: FH DE. Revised the manuscript for intellectual content: CCT AF VD. Screened, selected, and enrolled suitable participants in the imaging studies: JSP MG AF. Evaluated the subjects at each time point: JSP MG AF.