About the Authors

Trevor J. Morin

Affiliation Two Pore Guys Inc., Santa Cruz, CA, United States of America

Tyler Shropshire

Affiliation Two Pore Guys Inc., Santa Cruz, CA, United States of America

Xu Liu

Affiliation Two Pore Guys Inc., Santa Cruz, CA, United States of America

Kyle Briggs

Affiliation Department of Physics, University of Ottawa, Ontario, Canada

Cindy Huynh

Affiliation Two Pore Guys Inc., Santa Cruz, CA, United States of America

Vincent Tabard-Cossa

Affiliation Department of Physics, University of Ottawa, Ontario, Canada

Hongyun Wang

Affiliations Two Pore Guys Inc., Santa Cruz, CA, United States of America, Baskin School of Engineering, University of California Santa Cruz, Santa Cruz, CA, United States of America

William B. Dunbar

dunbar@soe.ucsc.edu

Affiliations Two Pore Guys Inc., Santa Cruz, CA, United States of America, Baskin School of Engineering, University of California Santa Cruz, Santa Cruz, CA, United States of America

Competing Interests

The authors of this manuscript have read the journal’s policy and have the following competing interests: TM, TS, XL, and CH are employees of Two Pore Guys, Inc. (TPG), a for-profit company. HW is a consultant for TPG and an employee of the University of California Santa Cruz. WBD is a co-founder and working for TPG while on leave from the University of California Santa Cruz. A research agreement between TPG and the University of California is in place that stipulates terms for the management of conflict of interests. A patent application with content related to this work was filed, entitled "Target Sequence Detection by Nanopore Sensing of Synthetic Probes", PCT/US2015/052729. The authors KB and VTC declare no competing financial interests. These Competing Interests statements do not alter the authors’ adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: TM TS VTC WBD. Performed the experiments: TM TS XL KB CH. Analyzed the data: KB VTC WBD. Contributed reagents/materials/analysis tools: TM TS CH VTC HW WBD. Wrote the paper: TM HW WBD.