About the Authors

D. Ransom Hardison

rance.hardison@noaa.gov

Affiliation National Oceanic and Atmospheric Administration, Center for Coastal Fisheries and Habitat Research, Beaufort, North Carolina, United States of America

William C. Holland

Affiliation National Oceanic and Atmospheric Administration, Center for Coastal Fisheries and Habitat Research, Beaufort, North Carolina, United States of America

Jennifer R. McCall

Affiliations University of North Carolina at Wilmington, MARBIONC at CREST Research Park, Wilmington, North Carolina, United States of America, SeaTox Research Inc, UNCW CREST Research Park, Wilmington, North Carolina, United States of America

Andrea J. Bourdelais

Affiliation University of North Carolina at Wilmington, MARBIONC at CREST Research Park, Wilmington, North Carolina, United States of America

Daniel G. Baden

Affiliation University of North Carolina at Wilmington, MARBIONC at CREST Research Park, Wilmington, North Carolina, United States of America

H. Taiana Darius

Affiliation Institut Louis Malardé (ILM)–UMR 241 EIO, Laboratory of Toxic-Microalgae, Papeete, Tahiti, French Polynesia

Mireille Chinain

Affiliation Institut Louis Malardé (ILM)–UMR 241 EIO, Laboratory of Toxic-Microalgae, Papeete, Tahiti, French Polynesia

Patricia A. Tester

Affiliations National Oceanic and Atmospheric Administration, Center for Coastal Fisheries and Habitat Research, Beaufort, North Carolina, United States of America, JHT, Inc., Orlando, Florida, United States of America

Damian Shea

Affiliation North Carolina State University, Environmental Chemistry and Toxicology Laboratory, Raleigh, North Carolina, United States of America

Harold A. Flores Quintana

Affiliation U.S. Food and Drug Administration, Division of Seafood Science and Technology, Gulf Coast Seafood Laboratory, Dauphin Island, Alabama, United States of America

James A. Morris Jr.

Affiliation National Oceanic and Atmospheric Administration, Center for Coastal Fisheries and Habitat Research, Beaufort, North Carolina, United States of America

R. Wayne Litaker

Affiliation National Oceanic and Atmospheric Administration, Center for Coastal Fisheries and Habitat Research, Beaufort, North Carolina, United States of America

Competing Interests

The commercial partner SeaTox Research Inc. was not responsible the design or execution of the project, nor did they provide salary support to any of the collaborators. Their role was limited to providing reagents and running the radioactive receptor binding assay using extracts prepared by DRH and WCH. The prepared samples were provided to JRM as numbered aliquots without any identification. Her results were then returned to DRH for comparison with his results. No collaborator except JRM has a commercial interest in SeaTox, including shares in the company, past salary compensation or royalties from any commercial kits that are sold. JHT provided support in the form of salary for PAT, but did not have any additional role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. This does not alter the authors' adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: DRH WCH JRM AJB DGB HTD MC PAT DS JAM RWL HFQ. Performed the experiments: DRH WCH JRM HFQ HTD. Analyzed the data: DRH WCH JAM AJB DGB HTD MC PAT DS HFQ JRM RWL. Contributed reagents/materials/analysis tools: DRH WCH JAM AJB DGB HTD MC PAT DS HFQ JRM RWL. Wrote the paper: DRH WCH JAM AJB DGB HTD MC PAT DS HFQ JRM RWL.