About the Authors

Calogera M. Simonaro

calogera.simonaro@mssm.edu

Affiliation Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, United States of America

Shunji Tomatsu

Affiliation Skeletal Dysplasia Laboratory, Nemours/Alfred I. duPont Hospital for Children, Wilmington, DE, United States of America

Tracy Sikora

Affiliation School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, United States of America

Francyne Kubaski

Affiliation Skeletal Dysplasia Laboratory, Nemours/Alfred I. duPont Hospital for Children, Wilmington, DE, United States of America

Michael Frohbergh

Affiliation Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, United States of America

Johana M. Guevara

Affiliations Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, United States of America, Pontificia Universidad Javeriana, Bogota, Colombia

Raymond Y. Wang

Affiliations Division of Metabolic Disorders, Children’s Hospital of Orange County, Orange, CA, United States of America, Division of Medical Genetics, Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA, United States of America

Moin Vera

Affiliation Division of Metabolic Disorders, Children’s Hospital of Orange County, Orange, CA, United States of America

Jennifer L. Kang

Affiliation Department of Neurosurgery, University of Pennsylvania, Philadelphia, PA, United States of America

Lachlan J. Smith

Affiliation Department of Neurosurgery, University of Pennsylvania, Philadelphia, PA, United States of America

Edward H. Schuchman

Affiliation Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, United States of America

Mark E. Haskins

Affiliation School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, United States of America

Competing Interests

A patent has been filed "Anti-TNF therapy for the mucopolysaccharidoses and other lysosomal storage diseases" (PCT/US2012/043369,WO2012177778) by Drs. Simonaro and Schuchman. This patent has not as yet been awarded. This does not alter the authors’ adherence to all PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: CMS EHS MEH. Performed the experiments: CMS EHS MEH ST TS FK MF JMG LJS RYW MV JLK. Analyzed the data: CMS EHS MEH ST LJS RYW. Contributed reagents/materials/analysis tools: CMS EHS MEH ST LJS. Wrote the paper: CMS EHS MEH.