About the Authors

Peili Chen

pchen@medicine.bsd.uchicago.edu (PC); gtoback@medicine.bsd.uchicago.edu (FGT)

Affiliation Department of Medicine, University of Chicago, Chicago, Illinois, 60637, United States of America

Maria Mancini

Affiliation Biomodels, LLC, Watertown, Massachusetts, 02472, United States of America

Stephen T. Sonis

Affiliations Biomodels, LLC, Watertown, Massachusetts, 02472, United States of America, Brigham and Women's Hospital, Boston, Massachusetts, 02115, United States of America

Juan Fernandez-Martinez

Affiliations Biomodels, LLC, Watertown, Massachusetts, 02472, United States of America, Mathematics Department, Universidad de Oviedo, Asturias, Spain

Jing Liu

Current address: Department of Pediatrics, University of Texas—Southwestern Medical Center, Dallas, Texas 75390, United States of America

Affiliation Department of Medicine, University of Chicago, Chicago, Illinois, 60637, United States of America

Ezra E. W. Cohen

Current address: Moores Cancer Center, University of California, San Diego, California 92093, United States of America

Affiliation Department of Medicine, University of Chicago, Chicago, Illinois, 60637, United States of America

F. Gary Toback

pchen@medicine.bsd.uchicago.edu (PC); gtoback@medicine.bsd.uchicago.edu (FGT)

Affiliation Department of Medicine, University of Chicago, Chicago, Illinois, 60637, United States of America

Competing Interests

The authors have the following interests. Maria Mancini, Stephen T. Sonis and Juan Fernandez-Martinez are employed by Biomodels, LLC. There are no patents, products in development or marketed products to declare. This did not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials, as detailed on-line in the guide for authors.

Author Contributions

Conceived and designed the experiments: PC FGT. Performed the experiments: PC MM JL. Analyzed the data: PC MM STS JFM JL EEWC FGT. Contributed reagents/materials/analysis tools: PC MM STS JFM JL EEWC FGT. Wrote the paper: PC MM STS EEWC FGT.