About the Authors

Masayuki Sugimoto

Affiliations Department of Integrated Molecular Imaging, Graduate School of Medicine, Hokkaido University, Sapporo, Japan, Shionogi Innovation Center for Drug Discovery, Discovery Research Laboratory for Innovative Frontier Medicines, Shionogi & Co., Ltd., Sapporo, Japan

Masato Wakabayashi

Affiliation Shionogi Innovation Center for Drug Discovery, Discovery Research Laboratory for Innovative Frontier Medicines, Shionogi & Co., Ltd., Sapporo, Japan

Yoichi Shimizu

Affiliations Central Institute of Isotope Science, Hokkaido University, Sapporo, Japan, Laboratory of Bioanalysis and Molecular Imaging, Faculty of Pharmaceutical Science, Hokkaido University, Sapporo, Japan

Takeshi Yoshioka

Affiliation Shionogi Innovation Center for Drug Discovery, Discovery Research Laboratory for Innovative Frontier Medicines, Shionogi & Co., Ltd., Sapporo, Japan

Kenichi Higashino

Affiliation Shionogi Innovation Center for Drug Discovery, Discovery Research Laboratory for Innovative Frontier Medicines, Shionogi & Co., Ltd., Sapporo, Japan

Yoshito Numata

Affiliation Shionogi Innovation Center for Drug Discovery, Discovery Research Laboratory for Innovative Frontier Medicines, Shionogi & Co., Ltd., Sapporo, Japan

Tomohiko Okuda

Affiliation Drug Discovery Technologies, Discovery Research Laboratory for Core Therapeutic Areas, Shionogi & Co., Ltd., Toyonaka, Japan

Songji Zhao

Affiliation Department of Tracer Kinetics & Bioanalysis, Graduate School of Medicine, Hokkaido University, Sapporo, Japan

Shota Sakai

Affiliation Department of Biomembrane and Biofunctional Chemistry, Faculty of Advanced Life Science, Hokkaido University, Sapporo, Japan

Yasuyuki Igarashi

Affiliation Department of Biomembrane and Biofunctional Chemistry, Faculty of Advanced Life Science, Hokkaido University, Sapporo, Japan

Yuji Kuge

kuge@ric.hokudai.ac.jp

Affiliations Department of Integrated Molecular Imaging, Graduate School of Medicine, Hokkaido University, Sapporo, Japan, Central Institute of Isotope Science, Hokkaido University, Sapporo, Japan

Competing Interests

Prof. Yuji Kuge and Yasuyuki Igarashi have received a research grant from Shionogi & Co., Ltd. Drs. Masayuki Sugimoto, Masato Wakabayashi, Takeshi Yoshioka, Kenichi Higashino, Yoshito Numata, and Tomohiko Okuda have employment at Shionogi & Co., Ltd. All the other authors have reported that they have no relationships relevant to the contents of this paper to disclose. The above interests do not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: MS TY KH YN SS YI YK. Performed the experiments: MS MW. Analyzed the data: MS MW YS TY. Contributed reagents/materials/analysis tools: MS MW YS TO SZ YK. Wrote the paper: MS YS YK.