About the Authors

Mark Ide

Affiliation Dental Institute, Kings College London, Guy's Hospital, London, United Kingdom

Marina Harris

Affiliation University of Southampton, Faculty of Medicine, Clinical Experimental Science, Southampton, United Kingdom

Annette Stevens

Affiliation Memory Assessment and Research Centre, Moorgreen Hospital, Southampton, United Kingdom

Rebecca Sussams

Affiliations University of Southampton, Faculty of Medicine, Clinical Experimental Science, Southampton, United Kingdom, Memory Assessment and Research Centre, Moorgreen Hospital, Southampton, United Kingdom

Viv Hopkins

Affiliation Memory Assessment and Research Centre, Moorgreen Hospital, Southampton, United Kingdom

David Culliford

Affiliation University of Southampton, Faculty of Health Sciences, NIHR CLAHRC Wessex Methodological Hub, Southampton, United Kingdom

James Fuller

Affiliation University of Southampton, Faculty of Natural and Environmental Science, Centre for Biological Sciences, Southampton, United Kingdom

Paul Ibbett

Affiliation University of Southampton, Faculty of Natural and Environmental Science, Centre for Biological Sciences, Southampton, United Kingdom

Rachel Raybould

Affiliation Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, United Kingdom

Rhodri Thomas

Affiliation Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, United Kingdom

Ursula Puenter

Affiliation University of Southampton, Faculty of Natural and Environmental Science, Centre for Biological Sciences, Southampton, United Kingdom

Jessica Teeling

Affiliation University of Southampton, Faculty of Natural and Environmental Science, Centre for Biological Sciences, Southampton, United Kingdom

V. Hugh Perry

Affiliation University of Southampton, Faculty of Natural and Environmental Science, Centre for Biological Sciences, Southampton, United Kingdom

Clive Holmes

ch4@soton.ac.uk

Affiliations University of Southampton, Faculty of Medicine, Clinical Experimental Science, Southampton, United Kingdom, Memory Assessment and Research Centre, Moorgreen Hospital, Southampton, United Kingdom

Competing Interests

The authors of this manuscript have the following competing interests. Prof. Holmes has received research support from the Dunhill Medical Trust. Dr. Ide has received research support from the Dunhill Medical Trust, the Oral and Dental Research Trust, Colgate Palmolive and GlaxoSmithKline. This does not alter the authors' adherence to PLOS ONE policies on sharing data and materials. No other competing interests were declared by the other authors.

Author Contributions

Conceived and designed the experiments: MI MH VHP CH. Performed the experiments: MH AS RS VH JF PI RR RT UP JT. Analyzed the data: CH DC. Contributed reagents/materials/analysis tools: MH JF RR JT VHP CH. Wrote the paper: CH MI DC.