About the Authors

Ken Sakaie

sakaiek@ccf.org

Affiliation Imaging Institute, Cleveland Clinic, Cleveland, Ohio, United States of America

Masaya Takahashi

Affiliation Advanced Imaging Research Center, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America

Gina Remington

Affiliation Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America

Xiaofeng Wang

Affiliation Quantitative Health Sciences, Cleveland Clinic, Cleveland, Ohio, United States of America

Amy Conger

Affiliation Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America

Darrel Conger

Affiliation Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America

Ivan Dimitrov

Affiliations Advanced Imaging Research Center, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America, Philips Medical Systems, Cleveland, Ohio, United States of America

Stephen Jones

Affiliation Imaging Institute, Cleveland Clinic, Cleveland, Ohio, United States of America

Ashley Frohman

Affiliation Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America

Teresa Frohman

Affiliation Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America

Koji Sagiyama

Affiliation Advanced Imaging Research Center, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America

Osamu Togao

Affiliation Advanced Imaging Research Center, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America

Robert J. Fox

Contributed equally to this work with: Robert J. Fox, Elliot Frohman

Affiliation Mellen Center, Cleveland Clinic, Cleveland, Ohio, United States of America

Elliot Frohman

Contributed equally to this work with: Robert J. Fox, Elliot Frohman

Affiliation Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America

Competing Interests

One of the authors, Dr. Dimitrov, was an employee of Philips Medical System at the time of this study. This commercial entity had no role in the study design, data collection and analysis decision to publish, or preparation of the manuscript. This does not alter the authors' adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: K. Sakaie RJF EF. Performed the experiments: MT GR AC DC ID AF TF K. Sagiyama OT EF. Analyzed the data: K. Sakaie XW RJF EF SJ. Contributed reagents/materials/analysis tools: K. Sakaie MT GR AC DC ID AF TF K. Sagiyama OT EF. Wrote the paper: K. Sakaie.