Repeated Activation of Lung Invariant NKT Cells Results in Chronic Obstructive Pulmonary Disease-Like Symptoms

Cheng-Chiu Tsao; Po-Nien Tsao; Yi-Guang Chen; Ya-Hui Chuang

doi:10.1371/journal.pone.0147710

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Open Access

Peer-reviewed

Research Article

Repeated Activation of Lung Invariant NKT Cells Results in Chronic Obstructive Pulmonary Disease-Like Symptoms

Cheng-Chiu Tsao,

Affiliation Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan
⨯
Po-Nien Tsao,

Affiliations Department of Pediatrics, College of Medicine, National Taiwan University, Taipei, Taiwan, The Research Center of Developmental Biology and Regenerative Medicine, National Taiwan University, Taipei, Taiwan
⨯
Yi-Guang Chen,

Affiliations Department of Pediatrics, Max McGee National Research Center for Juvenile Diabetes, Medical College of Wisconsin, Milwaukee, WI, 53226, United States of America, Human and Molecular Genetics Center, Medical College of Wisconsin, Milwaukee, WI, 53226, United States of America
⨯
Ya-Hui Chuang

* E-mail: yahuichuang@ntu.edu.tw

Affiliation Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan
⨯

Repeated Activation of Lung Invariant NKT Cells Results in Chronic Obstructive Pulmonary Disease-Like Symptoms

Cheng-Chiu Tsao,
Po-Nien Tsao,
Yi-Guang Chen,
Ya-Hui Chuang

Published: January 26, 2016
https://doi.org/10.1371/journal.pone.0147710

About the Authors

Cheng-Chiu Tsao

Affiliation Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan

Po-Nien Tsao

Affiliations Department of Pediatrics, College of Medicine, National Taiwan University, Taipei, Taiwan, The Research Center of Developmental Biology and Regenerative Medicine, National Taiwan University, Taipei, Taiwan

Yi-Guang Chen

Affiliations Department of Pediatrics, Max McGee National Research Center for Juvenile Diabetes, Medical College of Wisconsin, Milwaukee, WI, 53226, United States of America, Human and Molecular Genetics Center, Medical College of Wisconsin, Milwaukee, WI, 53226, United States of America

Ya-Hui Chuang

* E-mail: yahuichuang@ntu.edu.tw

Affiliation Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CCT PNT YHC. Performed the experiments: CCT YHC. Analyzed the data: CCT PNT YGC YHC. Contributed reagents/materials/analysis tools: CCT YHC. Wrote the paper: CCT PNT YGC YHC.

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Chronic obstructive pulmonary disease
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Macrophages
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Mouse models
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Cytokines
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Emphysema
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Inflammation
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Lymphocytes
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Neutrophils
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