About the Authors

Mark Paul-Clark

‡ These authors are joint first-authors.

Affiliation Imperial College London, London, United Kingdom

Wagdi Elsheikh

‡ These authors are joint first-authors.

Affiliation Department of Medicine, McMaster University, Hamilton, Ontario, Canada

Nicholas Kirkby

Affiliation Imperial College London, London, United Kingdom

Melissa Chan

Affiliation William Harvey Research Institute, London, United Kingdom

Pallavi Devchand

Affiliation Mount Sinai Hospital, Icahn Medical Institute, New York, United States of America

Terence A. Agbor

Affiliation Department of Medicine, McMaster University, Hamilton, Ontario, Canada

Kyle L. Flannigan

Affiliation Department of Medicine, McMaster University, Hamilton, Ontario, Canada

Charlotte Cheadle

Affiliation Imperial College London, London, United Kingdom

Maxim Freydin

Affiliation Imperial College London, London, United Kingdom

Angela Ianaro

Affiliation Department of Experimental Pharmacology, Universita di Napoli Federico II, Napoli, Italy

Jane A. Mitchell

Affiliation Imperial College London, London, United Kingdom

John L. Wallace

altapharm@hotmail.com

Affiliations Department of Physiology & Pharmacology, University of Calgary, Calgary, Alberta, Canada, Faculty of Medicine, Universidade Camilo Castelo Branco, São Paulo, SP, Brazil

Competing Interests

Dr. Wallace is the founder and a director of Antibe Therapeutics, which is developing ATB-346 as an anti-inflammatory drug. This does not alter the authors’ adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: MPC WE NK MC TAA KLF CC JAM JLW. Performed the experiments: MPC WE NK MC TAA KLF CC. Analyzed the data: MPC WE NK PD CC MF AI JAM JLW. Wrote the paper: MPC WE NK JAM JLW.