Myelin Basic Protein-Induced Production of Tumor Necrosis Factor-α and Interleukin-6, and Presentation of the Immunodominant Peptide MBP85-99 by B Cells from Patients with Relapsing-Remitting Multiple Sclerosis

Claus H. Nielsen; Lars Börnsen; Finn Sellebjerg; Marie K. Brimnes

doi:10.1371/journal.pone.0146971

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Peer-reviewed

Research Article

Myelin Basic Protein-Induced Production of Tumor Necrosis Factor-α and Interleukin-6, and Presentation of the Immunodominant Peptide MBP85-99 by B Cells from Patients with Relapsing-Remitting Multiple Sclerosis

Claus H. Nielsen ,

* E-mail: claus.henrik.nielsen@regionh.dk

Affiliation Institute for Inflammation Research, Center for Rheumatology and Spine Diseases, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark
⨯
Lars Börnsen,

Affiliation Department of Neurology, Copenhagen University Hospital Rigshospitalet, Danish Multiple Sclerosis Center, Copenhagen, Denmark
⨯
Finn Sellebjerg,

Affiliation Department of Neurology, Copenhagen University Hospital Rigshospitalet, Danish Multiple Sclerosis Center, Copenhagen, Denmark
⨯
Marie K. Brimnes

Affiliation Institute for Inflammation Research, Center for Rheumatology and Spine Diseases, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark
⨯

Myelin Basic Protein-Induced Production of Tumor Necrosis Factor-α and Interleukin-6, and Presentation of the Immunodominant Peptide MBP85-99 by B Cells from Patients with Relapsing-Remitting Multiple Sclerosis

Claus H. Nielsen,
Lars Börnsen,
Finn Sellebjerg,
Marie K. Brimnes

Published: January 12, 2016
https://doi.org/10.1371/journal.pone.0146971

About the Authors

Claus H. Nielsen

* E-mail: claus.henrik.nielsen@regionh.dk

Affiliation Institute for Inflammation Research, Center for Rheumatology and Spine Diseases, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark

Lars Börnsen

Affiliation Department of Neurology, Copenhagen University Hospital Rigshospitalet, Danish Multiple Sclerosis Center, Copenhagen, Denmark

Finn Sellebjerg

Affiliation Department of Neurology, Copenhagen University Hospital Rigshospitalet, Danish Multiple Sclerosis Center, Copenhagen, Denmark

Marie K. Brimnes

Affiliation Institute for Inflammation Research, Center for Rheumatology and Spine Diseases, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CHN MKB. Performed the experiments: MKB. Analyzed the data: CHN LB FS MKB. Contributed reagents/materials/analysis tools: LB FS. Wrote the paper: CHN FS MKB.

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B cells
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Cytokines
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Multiple sclerosis
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T cells
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Antigen presentation
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Antigen-presenting cells
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Patients
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Flow cytometry
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