Glucose Alters Per2 Rhythmicity Independent of AMPK, Whereas AMPK Inhibitor Compound C Causes Profound Repression of Clock Genes and AgRP in mHypoE-37 Hypothalamic Neurons

Johanneke E. Oosterman; Denise D. Belsham

doi:10.1371/journal.pone.0146969

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Peer-reviewed

Research Article

Glucose Alters Per2 Rhythmicity Independent of AMPK, Whereas AMPK Inhibitor Compound C Causes Profound Repression of Clock Genes and AgRP in mHypoE-37 Hypothalamic Neurons

Johanneke E. Oosterman,

Affiliations Department of Physiology, University of Toronto, Toronto, ON, Canada, Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
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Denise D. Belsham

* E-mail: d.belsham@utoronto.ca

Affiliations Department of Physiology, University of Toronto, Toronto, ON, Canada, Department of Obstetrics and Gynecology, University of Toronto, Toronto, ON, Canada, Department of Medicine, University of Toronto, Toronto, ON, Canada, Division of Cellular and Molecular Biology, Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada
⨯

Glucose Alters Per2 Rhythmicity Independent of AMPK, Whereas AMPK Inhibitor Compound C Causes Profound Repression of Clock Genes and AgRP in mHypoE-37 Hypothalamic Neurons

Johanneke E. Oosterman,
Denise D. Belsham

Published: January 19, 2016
https://doi.org/10.1371/journal.pone.0146969

About the Authors

Johanneke E. Oosterman

Affiliations Department of Physiology, University of Toronto, Toronto, ON, Canada, Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

Denise D. Belsham

* E-mail: d.belsham@utoronto.ca

Affiliations Department of Physiology, University of Toronto, Toronto, ON, Canada, Department of Obstetrics and Gynecology, University of Toronto, Toronto, ON, Canada, Department of Medicine, University of Toronto, Toronto, ON, Canada, Division of Cellular and Molecular Biology, Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JEO DDB. Performed the experiments: JEO. Analyzed the data: JEO DDB. Contributed reagents/materials/analysis tools: DDB. Wrote the paper: JEO DDB.

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Glucose
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Phosphorylation
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Circadian rhythms
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Neurons
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Gene expression
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Glucose metabolism
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Messenger RNA
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Circadian oscillators
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