About the Authors

Tadashi Moro

Affiliations Center for Matrix Biology and Medicine, Graduate School of Medicine, Tokai University, Isehara, Kanagawa, Japan, Department of Regenerative Medicine, Tokai University School of Medicine, Isehara, Kanagawa, Japan, Research Laboratory, Minophagen Pharmaceutical Co. Ltd., Zama, Kanagawa, Japan, CREST, Japan Science Technology/Japan Agency for Medical Research and Development, Chiyoda-ku, Tokyo, Japan

Sachie Nakao

Affiliations Center for Matrix Biology and Medicine, Graduate School of Medicine, Tokai University, Isehara, Kanagawa, Japan, Department of Regenerative Medicine, Tokai University School of Medicine, Isehara, Kanagawa, Japan

Hideaki Sumiyoshi

Affiliations Center for Matrix Biology and Medicine, Graduate School of Medicine, Tokai University, Isehara, Kanagawa, Japan, Department of Regenerative Medicine, Tokai University School of Medicine, Isehara, Kanagawa, Japan, CREST, Japan Science Technology/Japan Agency for Medical Research and Development, Chiyoda-ku, Tokyo, Japan

Takamasa Ishii

Affiliations Department of Molecular Life Science, Tokai University School of Medicine, Isehara, Kanagawa, Japan, Institute of Medical Sciences, Tokai University, Isehara, Kanagawa, Japan

Masaki Miyazawa

Current address: Department of Biological Sciences, North Carolina State University, Raleigh, North Carolina, United States of America

Affiliation Department of Molecular Life Science, Tokai University School of Medicine, Isehara, Kanagawa, Japan

Naoaki Ishii

Affiliations Department of Molecular Life Science, Tokai University School of Medicine, Isehara, Kanagawa, Japan, Institute of Medical Sciences, Tokai University, Isehara, Kanagawa, Japan

Tadayuki Sato

Affiliation Support Center for Medical Research and Education, Research and Promotion Division (Isehara), Tokai University, Isehara, Kanagawa, Japan

Yumi Iida

Affiliation Support Center for Medical Research and Education, Research and Promotion Division (Isehara), Tokai University, Isehara, Kanagawa, Japan

Yoshinori Okada

Affiliation Support Center for Medical Research and Education, Research and Promotion Division (Isehara), Tokai University, Isehara, Kanagawa, Japan

Masayuki Tanaka

Affiliation Support Center for Medical Research and Education, Research and Promotion Division (Isehara), Tokai University, Isehara, Kanagawa, Japan

Hideki Hayashi

Affiliation Support Center for Medical Research and Education, Research and Promotion Division (Isehara), Tokai University, Isehara, Kanagawa, Japan

Satoshi Ueha

Affiliations Department of Molecular Preventive Medicine, Graduate School of Medicine, University of Tokyo, Bunkyo-ku, Tokyo, Japan, CREST, Japan Science Technology/Japan Agency for Medical Research and Development, Chiyoda-ku, Tokyo, Japan

Kouji Matsushima

Affiliations Department of Molecular Preventive Medicine, Graduate School of Medicine, University of Tokyo, Bunkyo-ku, Tokyo, Japan, CREST, Japan Science Technology/Japan Agency for Medical Research and Development, Chiyoda-ku, Tokyo, Japan

Yutaka Inagaki

yutakai@is.icc.u-tokai.ac.jp

Affiliations Center for Matrix Biology and Medicine, Graduate School of Medicine, Tokai University, Isehara, Kanagawa, Japan, Department of Regenerative Medicine, Tokai University School of Medicine, Isehara, Kanagawa, Japan, Institute of Medical Sciences, Tokai University, Isehara, Kanagawa, Japan, CREST, Japan Science Technology/Japan Agency for Medical Research and Development, Chiyoda-ku, Tokyo, Japan

Competing Interests

The authors have declared that no competing interests exist. This commercial affiliation does not alter the authors' adherence to all PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: Y. Inagaki. Performed the experiments: TM SN TS Y. Iida YO MT HH. Analyzed the data: TM SN HS TI MM NI MT HH SU KM. Contributed reagents/materials/analysis tools: TI MM NI. Wrote the paper: TM Y. Inagaki.