About the Authors

N. J. Andersen

Affiliations Frederik Meijer Heart and Vascular Institute, Spectrum Hospital, 100 Michigan St. NE, Grand Rapids, MI, 49503, United States of America, Laboratory of Cancer and Developmental Cell Biology, Center for Cancer Cell Biology, Van Andel Research Institute, 333 Bostwick Ave. NE, Grand Rapids, MI, 49503, United States of America

E. A. Boguslawski

Affiliation Laboratory of Cancer and Developmental Cell Biology, Center for Cancer Cell Biology, Van Andel Research Institute, 333 Bostwick Ave. NE, Grand Rapids, MI, 49503, United States of America

A. S. Naidu

Affiliation Laboratory of Cancer and Developmental Cell Biology, Center for Cancer Cell Biology, Van Andel Research Institute, 333 Bostwick Ave. NE, Grand Rapids, MI, 49503, United States of America

C. Szot

Affiliation Tumor Angiogenesis Section, Center for Cancer Research, National Cancer Institute, Bldg. 560, Frederick, MD, 21702, United States of America

J. L. Bromberg-White

Affiliation Laboratory of Cancer and Developmental Cell Biology, Center for Cancer Cell Biology, Van Andel Research Institute, 333 Bostwick Ave. NE, Grand Rapids, MI, 49503, United States of America

K. Kits

Affiliations Laboratory of Cancer and Developmental Cell Biology, Center for Cancer Cell Biology, Van Andel Research Institute, 333 Bostwick Ave. NE, Grand Rapids, MI, 49503, United States of America, Partners in Science Program, Van Andel Education Institute, 333 Bostwick Ave NE, Grand Rapids, MI, 49503, United States of America

C. Y. Kuk

Affiliation Laboratory of Cancer and Developmental Cell Biology, Center for Cancer Cell Biology, Van Andel Research Institute, 333 Bostwick Ave. NE, Grand Rapids, MI, 49503, United States of America

L. E. Holton

Affiliation Frederik Meijer Heart and Vascular Institute, Spectrum Hospital, 100 Michigan St. NE, Grand Rapids, MI, 49503, United States of America

B. St. Croix

Affiliation Tumor Angiogenesis Section, Center for Cancer Research, National Cancer Institute, Bldg. 560, Frederick, MD, 21702, United States of America

C. M. Chambers

Affiliations Frederik Meijer Heart and Vascular Institute, Spectrum Hospital, 100 Michigan St. NE, Grand Rapids, MI, 49503, United States of America, Laboratory of Cancer and Developmental Cell Biology, Center for Cancer Cell Biology, Van Andel Research Institute, 333 Bostwick Ave. NE, Grand Rapids, MI, 49503, United States of America

N. S. Duesbery

duesbery@vai.org

Affiliation Laboratory of Cancer and Developmental Cell Biology, Center for Cancer Cell Biology, Van Andel Research Institute, 333 Bostwick Ave. NE, Grand Rapids, MI, 49503, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: NJA EAB ASN CS JLB-W BSC CMC NSD. Performed the experiments: NJA EAB ASN CS JLB-W KK CYK LEH BSC CMC NSD. Analyzed the data: NJA ASN CS JLB-W BSC CMC NSD. Drafted the manuscript: NSD. Contributed input to the writing of the manuscript: NJA EAB ASN CS JLB-W KK CYK LEH BSC CMC.