About the Authors

Anantha R. Nookala

Contributed equally to this work with: Anantha R. Nookala, Junhao Li

Affiliation Division of Pharmacology & Toxicology, School of Pharmacy, University of Missouri Kansas City, Kansas City, Missouri, United States of America

Junhao Li

Contributed equally to this work with: Anantha R. Nookala, Junhao Li

Affiliation Shanghai key laboratory of new drug design, School of Pharmacy, East China University of Science and Technology, Shanghai, China

Anusha Ande

Affiliation Division of Pharmacology & Toxicology, School of Pharmacy, University of Missouri Kansas City, Kansas City, Missouri, United States of America

Lei Wang

Affiliation Shanghai key laboratory of new drug design, School of Pharmacy, East China University of Science and Technology, Shanghai, China

Naveen K. Vaidya

Affiliation Department of Mathematics and Statistics, University of Missouri Kansas City, Kansas City, Missouri, United States of America

Weihua Li

Affiliation Shanghai key laboratory of new drug design, School of Pharmacy, East China University of Science and Technology, Shanghai, China

Santosh Kumar

Affiliation Department of Pharmaceutical Sciences, College of pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America

Anil Kumar

kumaran@umkc.edu

Affiliation Division of Pharmacology & Toxicology, School of Pharmacy, University of Missouri Kansas City, Kansas City, Missouri, United States of America

Competing Interests

AK is an editorial board member, but this does not alter the authors' adherence to all PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: AN NKV WL SK AK. Performed the experiments: AN JL AA LW. Analyzed the data: AN JL AA LW. Contributed reagents/materials/analysis tools: WL SK AK. Wrote the paper: AL WL SK AK.