About the Authors

Ida Rune

idarune@hotmail.com

Affiliation Section of Experimental Animal Models, Department of Veterinary Disease Biology, Faculty of Health and Medical Sciences, University of Copenhagen, Thorvaldsensvej 57, 1871 Frederiksberg C, Denmark

Bidda Rolin

Affiliation Global Research, Novo Nordisk A/S, Novo Nordisk Park 1, 2760 Måløv, Denmark

Christian Larsen

Affiliation Section of Experimental Animal Models, Department of Veterinary Disease Biology, Faculty of Health and Medical Sciences, University of Copenhagen, Thorvaldsensvej 57, 1871 Frederiksberg C, Denmark

Dennis Sandris Nielsen

Affiliation Department of Food Science, Faculty of Science, University of Copenhagen, Rolighedsvej 26, 1958 Frederiksberg C, Denmark

Jenny E. Kanter

Affiliation Department of Medicine, Diabetes and Obesity Center of Excellence, University of Washington, Seattle, WA, 98109, United States of America

Karin E. Bornfeldt

Affiliation Department of Medicine, Diabetes and Obesity Center of Excellence, University of Washington, Seattle, WA, 98109, United States of America

Jens Lykkesfeldt

Affiliation Section of Experimental Animal Models, Department of Veterinary Disease Biology, Faculty of Health and Medical Sciences, University of Copenhagen, Thorvaldsensvej 57, 1871 Frederiksberg C, Denmark

Karsten Buschard

Affiliation The Bartholin Institute, Rigshospitalet Dept. 3733, Copenhagen Biocenter, Ole Maaløes Vej 5, 2200 København N, Denmark

Rikke Kaae Kirk

Affiliation Global Research, Novo Nordisk A/S, Novo Nordisk Park 1, 2760 Måløv, Denmark

Berit Christoffersen

Affiliation Global Research, Novo Nordisk A/S, Novo Nordisk Park 1, 2760 Måløv, Denmark

Johannes Josef Fels

Affiliation Global Research, Novo Nordisk A/S, Novo Nordisk Park 1, 2760 Måløv, Denmark

Knud Josefsen

Affiliation The Bartholin Institute, Rigshospitalet Dept. 3733, Copenhagen Biocenter, Ole Maaløes Vej 5, 2200 København N, Denmark

Pernille Kihl

Affiliation Section of Experimental Animal Models, Department of Veterinary Disease Biology, Faculty of Health and Medical Sciences, University of Copenhagen, Thorvaldsensvej 57, 1871 Frederiksberg C, Denmark

Axel Kornerup Hansen

Affiliation Section of Experimental Animal Models, Department of Veterinary Disease Biology, Faculty of Health and Medical Sciences, University of Copenhagen, Thorvaldsensvej 57, 1871 Frederiksberg C, Denmark

Competing Interests

Several of the co-authors are employed by Novo Nordisk A/S. This does not alter the authors’ adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: IR BR JL BC AKH. Performed the experiments: IR CL JK JL RKK JJF KJ PK. Analyzed the data: IR JL JK. Contributed reagents/materials/analysis tools: KEB JJF KJ PK DSN. Wrote the paper: IR BR JL KEB KB AKH.