Two Chitotriose-Specific Lectins Show Anti-Angiogenesis, Induces Caspase-9-Mediated Apoptosis and Early Arrest of Pancreatic Tumor Cell Cycle

Ruby Singh; Laxman Nawale; Dhiman Sarkar; C. G. Suresh

doi:10.1371/journal.pone.0146110

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Open Access

Peer-reviewed

Research Article

Two Chitotriose-Specific Lectins Show Anti-Angiogenesis, Induces Caspase-9-Mediated Apoptosis and Early Arrest of Pancreatic Tumor Cell Cycle

Ruby Singh ,

Contributed equally to this work with: Ruby Singh, Laxman Nawale

Affiliation Biochemical Sciences Division, CSIR-National Chemical Laboratory, Pune, India
⨯
Laxman Nawale ,

Contributed equally to this work with: Ruby Singh, Laxman Nawale

Affiliation Combichem-Bioresource Center, CSIR-National Chemical Laboratory, Pune, India
⨯
Dhiman Sarkar ,

* E-mail: cg.suresh@ncl.res.in (CGS); d.sarkar@ncl.res.in (DS)

Affiliation Combichem-Bioresource Center, CSIR-National Chemical Laboratory, Pune, India
⨯
C. G. Suresh

* E-mail: cg.suresh@ncl.res.in (CGS); d.sarkar@ncl.res.in (DS)

Affiliation Biochemical Sciences Division, CSIR-National Chemical Laboratory, Pune, India
⨯

Two Chitotriose-Specific Lectins Show Anti-Angiogenesis, Induces Caspase-9-Mediated Apoptosis and Early Arrest of Pancreatic Tumor Cell Cycle

Ruby Singh,
Laxman Nawale,
Dhiman Sarkar,
C. G. Suresh

Published: January 21, 2016
https://doi.org/10.1371/journal.pone.0146110

About the Authors

Ruby Singh

Contributed equally to this work with: Ruby Singh, Laxman Nawale

Affiliation Biochemical Sciences Division, CSIR-National Chemical Laboratory, Pune, India

Laxman Nawale

Contributed equally to this work with: Ruby Singh, Laxman Nawale

Affiliation Combichem-Bioresource Center, CSIR-National Chemical Laboratory, Pune, India

Dhiman Sarkar

* E-mail: cg.suresh@ncl.res.in (CGS); d.sarkar@ncl.res.in (DS)

Affiliation Combichem-Bioresource Center, CSIR-National Chemical Laboratory, Pune, India

C. G. Suresh

* E-mail: cg.suresh@ncl.res.in (CGS); d.sarkar@ncl.res.in (DS)

Affiliation Biochemical Sciences Division, CSIR-National Chemical Laboratory, Pune, India

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: RS LN DS CGS. Performed the experiments: RS LN. Analyzed the data: RS LN DS CGS. Contributed reagents/materials/analysis tools: DS. Wrote the paper: RS LN DS CGS.

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Lectins
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Apoptosis
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Cancer treatment
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Pancreatic cancer
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Cell staining
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Mitochondria
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MTT assay
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Endothelial cells
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