About the Authors

Heiner Wedemeyer

wedemeyer.heiner@mh-hannover.de

Affiliation Department of Gastroenterology, Hepatology and Endocrinology at Hannover Medical School, Hannover, Germany

Xavier Forns

Affiliation Liver Unit, Hospital Clinic, IDIBAPS and CIBEREHD, Barcelona, Spain

Christophe Hézode

Affiliation Department of Hepatology and Gastroenterology, Hôpital Henri Mondor, INSERM U955, Université Paris-Est, Créteil, France

Samuel S. Lee

Affiliation Liver Unit, University of Calgary, Calgary, Canada

Astrid Scalori

Affiliation Global Product Development Immunology, Respiratory, Roche Products Ltd, Welwyn, United Kingdom

Athina Voulgari

Affiliation Global Product Development Clinical Science, Roche Products Ltd, Welwyn, United Kingdom

Sophie Le Pogam

Affiliation Clinical Development-Infectious Diseases, Genentech Inc., South San Francisco, California, United States of America

Isabel Nájera

Affiliation Roche Pharma and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Basel, Switzerland

James A. Thommes

Affiliation Product Development Immunology, Genentech Inc., South San Francisco, California, United States of America

Competing Interests

HW: has served as a consultant/speaker for Abbott, AbbVie, Biolex, BMS, Boehringer Ingelheim, Gilead Sciences, ITS, J&J/Janssen-Cilag, Medgenics, Merck/Schering-Plough, Novartis, Roche, Roche Diagnostics, Siemens, Transgene, ViiV; and has received research grants from Abbott, BMS, Gilead Sciences, Merck, Novartis, Roche, Roche Diagnostics, Siemens. XF: has received unrestricted grant support from Janssen and has served as an advisor for Janssen, Gilead and AbbVie. CH: has served as a consultant/speaker for Roche, Bristol-Myers Squibb, Merck, Janssen, AbbVie, and Gilead Sciences. SSL: Consulting for or research funding from: AbbVie, Achillion, Bristol Myers Squibb, Debiopharm, Gilead Sciences, GlaxoSmithKline, Janssen, Merck, Novartis, Roche, Vertex. Speakers Bureau: Bristol Myers Squibb, Gilead Sciences, Janssen, Merck, Roche, Vertex. AS: Employee of Roche Products Ltd. AV: Employee of Roche Products Ltd. SLP: Employee of Genentech Inc. IN: Employee of F. Hoffmann-La Roche Ltd. JAT: Employee of Genentech Inc. This does not alter the authors' adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: HW XF AS AV IN JAT. Performed the experiments: HW CH SL AS AV JAT. Analyzed the data: HW XF CH SL AS AV SLP IN JAT. Contributed reagents/materials/analysis tools: HW AV JAT. Wrote the paper: HW XF CH SL AS AV SLP IN JAT.