About the Authors

A. T. Cohen

Affiliation Guy’s and St Thomas’ Hospitals, King’s College, London, United Kingdom

M. Hamilton

Affiliation BMS, Princeton, United States of America

S. A. Mitchell

smitchell@dresourcesgroup.com

Affiliation Abacus International, Bicester, United Kingdom

H. Phatak

Affiliation BMS, Princeton, United States of America

X. Liu

Affiliation Pfizer, New York, United States of America

A. Bird

Affiliation Pfizer, Walton Oaks, United Kingdom

D. Tushabe

Affiliation TUSH-D UK LTD, Birmingham, United Kingdom

S. Batson

Affiliation Abacus International, Bicester, United Kingdom

Competing Interests

The authors have the following interests. This study was funded by Bristol Myers Squibb and Pfizer. Hamilton M. and Phatak H. are employed by Bristol Myers Squibb., Liu X. and Bird A. by Pfizer Ltd, Batson S. by Abacus International and Tushabe D. by TUSH-D UK LTD. At the time of this study, Claflin A. was a paid contractor of Pfizer Ltd. Cohen A. is a paid clinical consultant to Bristol Myers Squibb and Pfizer. Fowler H., Mitchell S.A., and Batson S. are paid consultants to Bristol Myers Squibb and Pfizer Ltd. There are no patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors.

Author Contributions

Analyzed the data: SB SAM MH. Wrote the paper: AC MH HP AB DT XL SAM SB. Defined the scope of the project: MH HP AB DT XL ATC SAM SB. Conducted the systematic review: SAM.