About the Authors

Jennifer D. Sisler

Affiliation Department of Biochemistry and Molecular Biology, and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA, 23298, United States of America

Magdalena Morgan

Affiliation Department of Biochemistry and Molecular Biology, and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA, 23298, United States of America

Vidisha Raje

Affiliation Department of Biochemistry and Molecular Biology, and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA, 23298, United States of America

Rebecca C. Grande

Affiliation Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, VA, 22908, United States of America

Marta Derecka

Affiliation Department of Biochemistry and Molecular Biology, and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA, 23298, United States of America

Jeremy Meier

Affiliation Department of Biochemistry and Molecular Biology, and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA, 23298, United States of America

Marc Cantwell

Affiliation Department of Biochemistry and Molecular Biology, and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA, 23298, United States of America

Karol Szczepanek

Affiliations Department of Biochemistry and Molecular Biology, and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA, 23298, United States of America, Medical Service, McGuire Department of Veterans Affairs Medical Center, Richmond, VA, 23249, United States of America

William J. Korzun

Affiliation Department of Clinical Chemistry, Virginia Commonwealth University, Richmond, VA, 23298, United States of America

Edward J. Lesnefsky

Affiliations Department of Biochemistry and Molecular Biology, and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA, 23298, United States of America, Medical Service, McGuire Department of Veterans Affairs Medical Center, Richmond, VA, 23249, United States of America, Department of Internal Medicine, Division of Cardiology, and Pauley Heart Center, Virginia Commonwealth University, Richmond, VA, 23298, United States of America

Thurl E. Harris

Affiliation Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, VA, 22908, United States of America

Colleen M. Croniger

Affiliation Department of Nutrition, Case Western University School of Medicine, Cleveland, OH, 44106, United States of America

Andrew C. Larner

alarner@vcu.edu

Affiliation Department of Biochemistry and Molecular Biology, and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA, 23298, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JDS MM VR MD JM MC EJL TEH CMC ACL. Performed the experiments: JDS MM JM EJL TEH CMC ACL KS. Analyzed the data: JDS JM EJL TEH CMC ACL. Contributed reagents/materials/analysis tools: KS WJK RCG TEH. Wrote the paper: JDS JM EJL CMC ACL.