About the Authors

Kosuke Fujita

Affiliation Skin Regeneration, PIAS Collaborative Research, UIC, Osaka University, Suita, Osaka, 565–0871, Japan

Katsunori Kuge

Affiliation Skin Regeneration, PIAS Collaborative Research, UIC, Osaka University, Suita, Osaka, 565–0871, Japan

Noriyasu Ozawa

Affiliations Skin Regeneration, PIAS Collaborative Research, UIC, Osaka University, Suita, Osaka, 565–0871, Japan, Research and Development Division, PIAS Corporation, Kobe, Hyogo, 651–2241, Japan

Shunya Sahara

Affiliations Skin Regeneration, PIAS Collaborative Research, UIC, Osaka University, Suita, Osaka, 565–0871, Japan, Research and Development Division, PIAS Corporation, Kobe, Hyogo, 651–2241, Japan

Kaori Zaiki

Affiliations Skin Regeneration, PIAS Collaborative Research, UIC, Osaka University, Suita, Osaka, 565–0871, Japan, Research and Development Division, PIAS Corporation, Kobe, Hyogo, 651–2241, Japan

Koichi Nakaoji

Affiliations Skin Regeneration, PIAS Collaborative Research, UIC, Osaka University, Suita, Osaka, 565–0871, Japan, Research and Development Division, PIAS Corporation, Kobe, Hyogo, 651–2241, Japan

Kazuhiko Hamada

Affiliation Research and Development Division, PIAS Corporation, Kobe, Hyogo, 651–2241, Japan

Yukiko Takenaka

Affiliation Organic Chemistry Department, Kobe Pharmaceutical University, Kobe, Hyogo, 658–8558, Japan

Takao Tanahashi

Affiliation Organic Chemistry Department, Kobe Pharmaceutical University, Kobe, Hyogo, 658–8558, Japan

Katsuto Tamai

Affiliation Division of Stem Cell Therapy Science, Graduate School of Medicine, Osaka University, Suita, Osaka, 565–0871, Japan

Yasufumi Kaneda

Affiliation Division of Gene Therapy Science, Graduate School of Medicine, Osaka University, Suita, Osaka, 565–0871, Japan

Akito Maeda

amaeda@uic.osaka-u.ac.jp

Affiliation Skin Regeneration, PIAS Collaborative Research, UIC, Osaka University, Suita, Osaka, 565–0871, Japan

Competing Interests

The authors have read the journal’s policy and have the following conflicts: This work was conducted as a joint research project between Osaka University and PIAS Corporation. NO, SS, KZ, KN, and KH are employed by a commercial company, PIAS Corporation. This study is related to the patent application on the effect of extracts of Mallotus philippinensis bark, filed by Osaka University and PIAS Corporation. This does not alter the authors' adherence to the policies of PLOS ONE on sharing data and materials.

Author Contributions

Conceived and designed the experiments: KF KK AM. Performed the experiments: KF KK NO SS KZ KN KH AM. Analyzed the data: KF KK NO SS KZ KN KH AM. Contributed reagents/materials/analysis tools: YT TT. Wrote the paper: KF AM. Supervised the study design, execution, and analysis: KT YK AM.