About the Authors

Claudia Spies

Contributed equally to this work with: Claudia Spies, Alawi Luetz

claudia.spies@charite.de

Affiliation Department of Anesthesiology and Intensive Care Medicine, Campus Charité Mitte and Campus Virchow-Klinikum, Charité – Universitätsmedizin, Berlin, Germany

Alawi Luetz

Contributed equally to this work with: Claudia Spies, Alawi Luetz

Affiliation Department of Anesthesiology and Intensive Care Medicine, Campus Charité Mitte and Campus Virchow-Klinikum, Charité – Universitätsmedizin, Berlin, Germany

Gunnar Lachmann

Affiliation Department of Anesthesiology and Intensive Care Medicine, Campus Charité Mitte and Campus Virchow-Klinikum, Charité – Universitätsmedizin, Berlin, Germany

Markus Renius

Affiliation Department of Anesthesiology and Intensive Care Medicine, Campus Charité Mitte and Campus Virchow-Klinikum, Charité – Universitätsmedizin, Berlin, Germany

Clarissa von Haefen

Affiliation Department of Anesthesiology and Intensive Care Medicine, Campus Charité Mitte and Campus Virchow-Klinikum, Charité – Universitätsmedizin, Berlin, Germany

Klaus-Dieter Wernecke

Affiliation Sostana GmbH, Berlin, Germany

Marcus Bahra

Affiliation Department of General, Abdominal and Transplantation Surgery, Charité – Universitätsmedizin Berlin, Campus Virchow-Klinikum, Berlin, Germany

Alexander Schiemann

Affiliation Department of Anesthesiology and Intensive Care Medicine, Campus Charité Mitte and Campus Virchow-Klinikum, Charité – Universitätsmedizin, Berlin, Germany

Marco Paupers

Affiliation Department of Anesthesiology and Intensive Care Medicine, Campus Charité Mitte and Campus Virchow-Klinikum, Charité – Universitätsmedizin, Berlin, Germany

Christian Meisel

Affiliation Institute of Medical Immunology, Charité – Universitätsmedizin Berlin, Campus Virchow-Klinikum, Berlin, Germany

Competing Interests

Deutsche Forschungsgemeinschaft DFG SP432-1, http://www.dfg.de/. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Charité - Universitätsmedizin Berlin (www.charite.de). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. See ICMJE Statistical analysis has been supervised by Professor Klaus-Dieter Wernecke, PhD, former head of the Institute of Medical Biometry at Charité - Universitätsmedizin Berlin and owner of Sostana GmbH. The authors confirm that it does not alter the authors' adherence to all PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: CDS MR AL. Performed the experiments: MR AS MP GL. Analyzed the data: CDS GL AL KW. Contributed reagents/materials/analysis tools: CVH CM MB. Wrote the paper: CDS AL GL KW.